| 硫代部花菁类染料生物成像及诊疗的研究进展 |
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| 引用本文： | 姚善昆,丁伟忠,吴延平,陈韵聪,郭子建.硫代部花菁类染料生物成像及诊疗的研究进展[J].高等学校化学学报,2022,43(12):20220568. |
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| 作者姓名： | 姚善昆 丁伟忠 吴延平 陈韵聪 郭子建 |
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| 作者单位： | 南京大学化学化工学院, 配位化学国家重点实验室, 化学和生物医药创新研究院, 南京 210023 |
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| 基金项目： | 国家自然科学基金(22122701);江苏省自然科学基金(BK20202004);南京大学卓越计划项目(ZYJH004) |
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| 摘 要： | 硫代部花菁是氮杂环阳离子和末端氨基、 羟基或烷氧基通过π共轭桥连在一起的一类荧光染料, 具有优异的光学性质和生物相容性, 其近红外发射优势以及光敏特性使以硫代部花菁为骨架的荧光探针和诊疗试剂在荧光/光声成像和肿瘤治疗方面发挥着重要作用. 本文综合评述了基于硫代部花菁构建的荧光探针和诊疗分子在识别各种生命或环境分析物以及光基疗法中的研究及应用, 讨论了该领域面临的问题， 并对未来的发展趋势进行了展望.
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| 关 键 词： | 硫代部花菁 荧光探针 光动力治疗 光热治疗 |
| 收稿时间： | 2022-08-26 |
Research Progress in Bioimaging and Theranostics of Thioxanthene-hemicyanine Dyes |
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| YAO Shankun,DING Weizhong,WU Yanping,CHEN Yuncong,GUO Zijian.Research Progress in Bioimaging and Theranostics of Thioxanthene-hemicyanine Dyes[J].Chemical Research In Chinese Universities,2022,43(12):20220568. |
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| Authors: | YAO Shankun DING Weizhong WU Yanping CHEN Yuncong GUO Zijian |
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| Institution: | School of Chemistry and Chemical Engineering，State Key Laboratory of Coordination Chemistry，Chemistry and Biomedicine Innovation Center（ChemBIC），Nanjing University，Nanjing 210023，China |
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| Abstract: | Thioxanthene-hemicyanine is a fluorescent dye in which a nitrogen heterocyclic cation moiety and a terminal amino， hydroxyl or alkoxy amino group are linked by π-conjugated bridge. Thioxanthene-hemicyanine has outstanding photophysical properties and great biocompatibility， and its unique near-infrared emission and photosensitive features enable it to play a crucial role in the study of fluorescence detection and tumor therapy. This article reviews the research and application of thioxanthene-hemicyanine-based fluorescent probes and photosensitive molecules in the recognition of various biomarkers and phototherapy of diseases， respectively. |
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| Keywords: | Thioxanthene-hemicyanine Fluorescent probe Photodynamic therapy Photothermal therapy |
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