| 自组装多肽探针在磁共振成像中的应用 |
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| 引用本文： | 徐海东,王睿,梁高林.自组装多肽探针在磁共振成像中的应用[J].高等学校化学学报,2022,43(12):20220440. |
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| 作者姓名： | 徐海东 王睿 梁高林 |
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| 作者单位： | 东南大学生物科学与医学工程学院, 生物电子学国家重点实验室, 南京 210096 |
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| 基金项目： | 国家自然科学基金(21725505);南京大学“生命分析化学国家重点实验室”开放课题(SKLACLS2215) |
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| 摘 要： | 磁共振成像(MRI)是一种强大的非侵入式生物医学诊断技术. 临床上, MRI需要借助造影剂来提高成像质量, 从而提高诊断的准确性. 由于具有优越的信号放大能力和生物相容性, 自组装多肽探针可负载特定的MRI分子, 通过酶促自组装过程实现肿瘤靶向和特异性富集, 增强肿瘤病灶区MRI信号, 从而进一步提高MRI的准确性和灵敏度. 本综述总结了近年来多肽自组装探针在不同MRI模式( 1H MRI, 19F MRI和双自旋核MRI)下的最新进展, 并展望了这类新型探针在MRI领域的应用前景.
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| 关 键 词： | 自组装多肽 酶响应MRI探针 1H MRI 19F MRI 肿瘤成像 |
| 收稿时间： | 2022-06-21 |
Applications of Self-assembled Peptide Probes in Magnetic Resonance Imaging |
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| XU Haidong,WANG Rui,LIANG Gaolin.Applications of Self-assembled Peptide Probes in Magnetic Resonance Imaging[J].Chemical Research In Chinese Universities,2022,43(12):20220440. |
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| Authors: | XU Haidong WANG Rui LIANG Gaolin |
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| Institution: | School of Biological Science and Medical Engineering，State Key Laboratory of Bioelectronics，Southeast University，Nanjing 210096，China |
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| Abstract: | Magnetic resonance imaging（MRI） is a powerful non-invasive biomedical diagnostic technique. Clinically， MRI requires contrast agents to improve imaging quality， thereby improving the diagnosis accuracy. Due to the superior signal amplification ability and biocompatibility， self-assembled peptide probes can be loaded with specific MRI molecules to achieve tumor targeting and enriching through the enzyme responsive self-assembly process. Thus， self-assembled peptide probes can enhance the MRI signal of tumor lesions， thereby further improving the accuracy and sensitivity of MRI. This review summarizes the recent progress of self-assembled peptide probes under different MRI modalities（ 1H MRI， 19F MRI， dual nuclei MRI）， and highlights their potential for cancer diagnosis. |
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| Keywords: | Self-assembled polypeptide Enzyme responsive MRI probe 1H MRI 19F MRI Tumor imaging |
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