磁粒子成像示踪剂的研究进展

磁粒子成像是基于功能和断层影像技术检测磁性纳米粒子空间分布的示踪方法, 具有正向的对比信号、 较低的组织背景、 无限的组织穿透深度、 非侵入性成像以及无电离辐射等优点, 是近年来一种很有前途的生物医学成像技术. 磁粒子成像信号是通过在无场点切换磁性纳米粒子的磁自旋矢量来产生的. 磁粒子成像的灵敏度和空间分辨率都高度依赖于作为磁粒子成像示踪剂的磁性纳米粒子本身的磁性能, 因此目前的研究主要集中在磁性纳米粒子的设计和合成上. 本文重点介绍了磁粒子成像示踪剂的最新研究进展, 总结了可作为磁粒子成像示踪剂的磁性纳米粒子的种类、 合成方法、 性能以及生物医学应用, 以期为磁粒子成像的未来研究提供参考.

Recent Development of Magnetic Particle Imaging Tracers

Magnetic particle imaging（MPI） is a tracer method based on functional and tomography imaging techniques to detect the spatial distribution of magnetic nanoparticles（MNPs）， the contrast of positive signal， low background， infinite tissue penetration depth， non-invasive imaging as well as the advantages of no ionizing radiation， which is a promising biomedical imaging technology in recent years. The MPI signal is generated by switching the magnetic spin vector of MNPs at field-free points（FFP）. The imaging sensitivity and spatial resolution of MPI are highly dependent on the magnetic properties of MNPs themselves as MPI tracers， so the current research is mainly focused on the design and synthesis of MNPs. This review focuses on the latest research progress of MPI tracers， and summarizes the types， synthesis methods， properties and biomedical applications of MNPs that can be used as MPI tracers， in order to provide reference for the future development of MPI.