单原子材料类酶催化及生物医学应用研究进展

纳米酶因其经济、 稳定、 性质可调和可循环利用等诸多优势, 成功地克服了天然酶在实际应用中的不足. 单原子材料的出现使得对纳米酶的研究迈入原子水平, 其较高的原子利用率、 独特的配位环境和较强的金属-载体相互作用为揭示纳米酶构效关系及调控类酶活性提供了可能. 本文总结了近年来单原子材料类酶催化的研究进展, 重点讨论了单原子材料类酶活性的调控策略和催化机理, 概述了单原子类酶材料在癌症治疗、 抗氧化治疗、 抗菌以及生物传感等方面的应用, 并对单原子类酶材料的发展前景进行了展望.

Recent Advances in Single-atom Materials for Enzyme-like Catalysis and Biomedical Applications

Nanozymes featuring with economic cost， high stability， tunable properties， have captured broad interest to break through the limitations of enzymes in practice. The emergency of single-atom materials pushes forward the nanozymes research into the atomic level. Single-atom materials with high atomic utilization efficiency， unique coordination environments and strong metal-support interactions offer great opportunities to reveal their structure-activity relationship and regulate their enzyme-like activities. In this review， recent advances of single-atom materials for enzyme mimicking and biomedical applications were depicted. First， the regulation strategies and catalytic mechanisms of enzyme-like activities were discussed in detail. Then， the applications of single-atom nanomaterials for enzyme mimicking were elucidated in terms of cancer treatment， antioxidant therapy， antibacterial and biosensing. Finally， the limitations， challenges and development prospects of single-atom nanomaterials for enzyme-like catalysis were proposed.