| 1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物的合成及其抗肿瘤活性研究 |
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| 引用本文： | 丁齐柱,罗宣干,卓仁禧.1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环[3,3,3]十一烷衍生物的合成及其抗肿瘤活性研究[J].高等学校化学学报,1989,10(10):1007. |
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| 作者姓名： | 丁齐柱 罗宣干 卓仁禧 |
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| 作者单位： | 武汉大学化学系 |
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| 摘 要： | 通过1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环3,3,3]十一烷与酸反应或1-(3-氯丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环3,3,3]十一烷与胺反应,合成了14种1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环3,3,3]十一烷衍生物.体外细胞培养试验结果表明,某些1-(3-氨基丙基)-2,8,9-三氧杂-5-氮杂-1-硅杂双环3,3,3]十一烷衍生物对艾氏腹水癌细胞具有较好的杀伤活性.
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| 关 键 词： | 抗肿瘤活性 2 8 9-三氧杂-5-氮杂-1-硅杂双环[3 3 3]十一烷 1-(3-氨基丙基)-2 8 9-三氧杂-5-氮杂-1-硅杂双环[3 3 3]十一烷 1-(3-氯丙基)-2 8 9-三氧杂-5-氮杂-1-硅杂双环[3 3 3]十一烷 |
| 收稿时间： | 1988-05-14 |
Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives |
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| Ding Qizhu,Luo Xuangan,Zhuo Renxi.Studies on the Synthesis and Antitumor Activity of 3-Aminopropylsilatrane Derivatives[J].Chemical Research In Chinese Universities,1989,10(10):1007. |
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| Authors: | Ding Qizhu Luo Xuangan Zhuo Renxi |
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| Institution: | Department of chemistry, Wuhan University, Wuhan |
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| Abstract: | Fourteen new derivatives of 3-aminopropylsilatrane were synthesized by the reaction of 3-aminopropylsilatrane with acids or 3-chloropropylsilatrane with amines. The structures of these compounds were identified with 1H NMR , IR and elemental analysis. The results of in vitro cell culture testing showed that some of the silatrane derivatives exhibit good antitumor activity. |
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| Keywords: | Antitumor activity 2 8 9-Trioxa-5-aza-1-silabicyclo[3 3 3]undecane 3-Aminopropyl-2 8 9-trioxa-5-aza-1-silabicyclo[3 3 3]undecane 3-Chloropropyl-2 8 9-trioxa-5-aza-1-silabicy-clo[3 3 3]undecane |
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