| 二聚体有机锡配合物{[n-Bu2SnO2CCH(CS2NEt2)2]2O}2的合成、表征及晶体结构 |
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| 引用本文： | 尹汉东,薛绳才,王其宝.二聚体有机锡配合物{[n-Bu2SnO2CCH(CS2NEt2)2]2O}2的合成、表征及晶体结构[J].高等学校化学学报,2005,26(4):631-633. |
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| 作者姓名： | 尹汉东 薛绳才 王其宝 |
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| 作者单位： | 聊城大学化学化工学院, 聊城 252059 |
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| 基金项目： | 中国科学院资助项目;教育部科学技术研究项目 |
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| 摘 要： | 近年来，有机锡(Ⅳ)的羧酸配合物因其具有很强的生物活性以及丰富的结构类型备受人们的重视．实验证明，它们的生物活性与锡原子的配位形式有关，而中心锡原子的配位形式决定于直接与锡原子相连的烃基的结构和羧酸基配体的类型。
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| 关 键 词： | 有机锡配合物 双(N N-二乙基二硫代甲氨酰)乙酸 合成 晶体结构 生物活性 |
| 文章编号： | 0215-0790(2005)04-0631-03 |
| 收稿时间： | 2004-03-16 |
Synthesis, Characterization and Crystal Structure of Dimer Organotin Complex {[n-Bu2SnO2CCH(CS2NEt2)2]2O}2 |
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| YIN Han-Dong,XUE Sheng-Cai,WANG Qi-Bao.Synthesis, Characterization and Crystal Structure of Dimer Organotin Complex {[n-Bu2SnO2CCH(CS2NEt2)2]2O}2[J].Chemical Research In Chinese Universities,2005,26(4):631-633. |
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| Authors: | YIN Han-Dong XUE Sheng-Cai WANG Qi-Bao |
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| Institution: | Department of Chemistry, Liaocheng University, Liaocheng 252059, China |
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| Abstract: | The title complex {nBu2SnO2CCH(CS2NEt2)2]2O}2 was synthesized and characterized by elemental analysis, IR, NMR and Xray single crystal diffraction. The results show that the complex belongs to a monoclinic system with space group C2/c, and unit cell dimensions: a=2.848(5) nm, {b=1.381(2) nm}, c=3.239(6) nm, β=111.11(2)°, Z=4, V=11.884(35) nm3, D-c=1.329 g/cm3, {F(000)}=4 912, S=0.991, R-1=0.053 5, wR2=0.116 6. The complex has a centrosymmetric dimer structure mode with a fourmembered central endocyclic Sn2O2 unit. The endocyclic tin atoms are sixcoordination and have coordition geometry of distorted octahedron. The exocyclic tin atoms are fivecoordination and have coordination geometry of distorted trigonal bipyramid. This complex was tested in vitro against human tumour cell lines, MCF-7 and WiDr, and displayed the higher activity. |
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| Keywords: | Organotin complex Bis(N N-diethyldithiocarbamyl)acetate} Synthesis Crystal structure Biological activity |
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