| 1,4-双(9-O-奎宁)-2,3-二氮杂萘-OsO4催化烯烃的不对称氨羟化反应 |
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| 引用本文： | 程司堃,匡永清,路丽华,李晓晔,张生勇.1,4-双(9-O-奎宁)-2,3-二氮杂萘-OsO4催化烯烃的不对称氨羟化反应[J].高等学校化学学报,2004,25(4):651-653. |
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| 作者姓名： | 程司堃 匡永清 路丽华 李晓晔 张生勇 |
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| 作者单位： | 第四军医大学化学教研室,西安,710032 |
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| 基金项目： | 国家自然科学基金(批准号: 29972055, 20002008)资助. |
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| 摘 要： | 在氧化-供氮试剂N-氯代氨基甲酸苄酯存在下,1,4-双(9-O-奎宁)-2,3-二氮杂萘-OsO4催化剂在5种烯烃的不对称氨羟化反应中表现出极高的对映选择性(85%～99%e.e.)和区域选择性,产率48%～68%.
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| 关 键 词： | 1 4-双(9-O-奎宁)-2 3-二氮杂萘 不对称氨羟化反应 手性β-氨基醇 |
| 文章编号： | 0251-0790(2004)04-0651-03 |
| 收稿时间： | 2003-03-24 |
Asymmetric Aminohydroxylation of Olefins Catalyzed by 1,4-Bis(9-O-quininyl)phthalazine-OsO4 Complex |
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| CHENG Si-Kun,KUANG Yong-Qing,LU Li-Hua,LI Xiao-Ye,ZHANG Sheng-Yong.Asymmetric Aminohydroxylation of Olefins Catalyzed by 1,4-Bis(9-O-quininyl)phthalazine-OsO4 Complex[J].Chemical Research In Chinese Universities,2004,25(4):651-653. |
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| Authors: | CHENG Si-Kun KUANG Yong-Qing LU Li-Hua LI Xiao-Ye ZHANG Sheng-Yong |
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| Institution: | CHENG Si-Kun,KUANG Yong-Qing,LU Li-Hua,LI Xiao-Ye,ZHANG Sheng-Yong * |
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| Abstract: | Five olefins were aminohydroxylated enantiomerically catalyzed by 1,4-bis(9-O-quininyl)phthalazine-OsO4 complex in the presence of benzyl N-chlorocarbamate(oxidant and nitrogen source). Excellent enantioselectivity(85%—99% e.e.) as well as specific regio and chemoselectivity were observed and isolated yield of the products 48%—68% was achieved. The results are comparable to those of the best catalyst reported for AA reaction. |
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| Keywords: | Bis(9-O-quininyl)phthalazine Asymmetric aminohydroxylation Chiral β-amino alcohol |
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