| 大萼香茶菜中的新二萜化合物 |
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| 引用本文： | 石浩,何山,何兰,潘远江.大萼香茶菜中的新二萜化合物[J].高等学校化学学报,2007,28(1):100-102. |
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| 作者姓名： | 石浩 何山 何兰 潘远江 |
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| 作者单位： | 1. 浙江大学化学系,杭州,310027
2. 北京师范大学化学系,北京,100085 |
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| 基金项目： | 国家自然科学基金
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浙江省自然科学基金 |
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| 摘 要： | 报道从大萼香茶菜叶的乙醇提取物中分离得到一种新的二萜类化合物, 并命名为大萼香茶菜癸素(1). 其药理活性实验结果证明, 该化合物对体外培养的Hela细胞有较强的抑制作用.
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| 关 键 词： | 大萼香茶菜 B断裂贝壳杉烯 大萼香茶菜癸素 |
| 文章编号： | 0251-0790（2007）01-0100-03 |
| 收稿时间： | 2006-01-15 |
| 修稿时间： | 2006-01-15 |
New Diterpenoid Compound from Rabdosia macrocalyx |
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| SHI Hao,HE Shan,HE Lan,PAN Yuan-Jiang.New Diterpenoid Compound from Rabdosia macrocalyx[J].Chemical Research In Chinese Universities,2007,28(1):100-102. |
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| Authors: | SHI Hao HE Shan HE Lan PAN Yuan-Jiang |
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| Institution: | 1. Department of Chemistry, Zhejiang University, Hangzhou 310027, China; 2. Department of Chemistry, Beijing Normal University, Beijing 100085, China |
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| Abstract: | On the basis of the investigation on natural product antitumor agents, a new diterpenoid named macrocalyxin J was isolated from the leaves of Rabdosia macrocalyx(Dunn) Hara by silica gel column chromatography. Based on IR, MS, 1H NMR, 13C NMR and 2D NMR spectroscopies, the structure of macrocalyxin J was determined as (1α,6β,11β,14α)-1,7∶6,20-diepoxy-6,11-dihydroxy-6,7-seco-ent-kaur-16-ene-7,15-dione-14-acetate. The antitumor activity of the compound was assayed by MTT method. Macrocalyxin J was shown to have a potency in vitro against the cultures of Hela cells. |
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| Keywords: | Rabdosia macrocalyx B-seco-ent-kaurene Macrocalyxin J |
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