层层静电自组装构建壳聚糖/肝素抗菌多层膜的研究

聚对苯二甲酸乙二醇酯（PET）由于其突出的机械性能和良好的生物相容性而广泛用作心血管的植入材料，但是植入内置医用材料时会发生感染，这直接导致了较高的发病率和死亡率，传统的抗感染的表面设计包括与抗菌药物机械共混和表面化学接枝抗菌药物等，但是采用简单的机械共混方式制备的材料中药物负载可控性差，表面化学接枝涉及步骤繁杂的合成工艺很难在具有复杂体型结构的医用装置上实现，因此寻求一种简单的面对装置的表面修饰手段成为医用装置抗感染表面设计的关键性问题。

Construction of Anti-bacterial Multilayer Films via Layer-by-layer Electro Static Self-assembly of Chitosan and Heparin

Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly(ethylene terephthalate)(PET) to construct anti-adhesive and antibacterial multilayer films.The contact angle and UV data verified the progressive build-up of the multilayer film by alternate deposition of the polyelectrolytes.PRT experiment and in vitro antibacterial assay indicated that the multilayer-modified PET films had much better hemocompatibility and much stronger antibacterial performance than(unmodified) PET.Such an easy processing and shape-independent method to prepare an anti-adhesive and(antibacterial) surface may have a good potential for surface modification of cardiovascular devices.