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南中国海星骨海绵Stelletta sp.中的三萜化合物
引用本文:蓝文健,林翠梧,苏镜娱,曾陇梅.南中国海星骨海绵Stelletta sp.中的三萜化合物[J].高等学校化学学报,2005,26(12):2270-2272.
作者姓名:蓝文健  林翠梧  苏镜娱  曾陇梅
作者单位:1. 中山大学药学院,广州,510080
2. 广西大学化学与化学工程学院,南宁,530004
3. 中山大学化学与化学工程学院,广州,510275
摘    要:Stelletta属海绵的次生代谢产物中主要含有生物碱、甾类和萜类等化合物,其中最引人注目的当属具有长链共轭体系的三萜化合物.McCabe等从星骨海绵Stelletta sp.中首次分离出一个异臭春类(Isomalabaricane)碳架的黄色三萜色素,其后,苏镜娱等㈨也从Stelletta tenuis Lindgren中得到C13,C14双键呈E构型的异臭春类三萜色素(Stellertin A),Stellertin A对P388肿瘤细胞有强烈的抑制活性,ED50值为0.001μg/mL.

关 键 词:海绵  星骨属海绵  三萜化合物  抗肿瘤
文章编号:0251-0790(2005)12-2270-03
收稿时间:2004-12-28
修稿时间:2004-12-28

Triterpenoids from the Sponge Stelletta sp. Collected from the South China Sea
LAN Wen-Jian,LIN Cui-Wu,SU Jing-Yu,ZENG Long-Mei.Triterpenoids from the Sponge Stelletta sp. Collected from the South China Sea[J].Chemical Research In Chinese Universities,2005,26(12):2270-2272.
Authors:LAN Wen-Jian  LIN Cui-Wu  SU Jing-Yu  ZENG Long-Mei
Institution:1. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China; 2. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China ; School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
Abstract:Three isomalabaricane and malabaricane triterpenoids(1-3) were isolated from the sponge Stelletta sp.collected from Weizhou Island,Guangxi Province.The structures of compounds 1-3 were identified mainly by spectroscopic methods and X-ray diffraction analysis.All 1H NMR and 13C NMR signals of compound 1 were assigned for the first time on the basis of HMQC,1H-1H COSY and HMBC experiment.Antitumor assay exhibits that compounds 1,2 and 3 have a significant antitumor activity against P388 tumor cell lines with ED50 values 0.01,0.5,1.0 μg/mL,respectively.
Keywords:Sponge  Stelletta sp    Triterpenoid  Antitumor activity
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