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直链淀粉手性固定相对8种外消旋硫代缩水甘油醚的直接拆分
引用本文:周志强,丁二润,胡雨来,于兆文,陈立仁.直链淀粉手性固定相对8种外消旋硫代缩水甘油醚的直接拆分[J].高等学校化学学报,1998,19(11):1755-1757.
作者姓名:周志强  丁二润  胡雨来  于兆文  陈立仁
作者单位:中国科学院兰州化学物理研究所,兰州,730000
基金项目:中国科学院重点项目基金
摘    要:利用高效液相色谱进行不对称拆分是十分有效的方法,其中多糖类手性固定相是非常重要的一种,它主要包括纤维素和淀粉两大类,Okamoto等[1~3]合成了大量的纤维素和直链淀粉的衍生物,并将其涂敷在大孔硅胶表面,从而制备了手性拆分能力较强的多种固定相,这类...

关 键 词:HPLC  直链淀粉  手性固定相  硫代缩水甘油醚  拆分

Direct Enantiomeric Resolution of Eight Kinds of Thio-glycidyl Ether Using Amylose-chiral Stationary Phase by HPLC
ZHOU Zhi-Qiang,DING Er-Run,HU Yu-Lai,YU Zhao-Wen,CHEN Li-Ren.Direct Enantiomeric Resolution of Eight Kinds of Thio-glycidyl Ether Using Amylose-chiral Stationary Phase by HPLC[J].Chemical Research In Chinese Universities,1998,19(11):1755-1757.
Authors:ZHOU Zhi-Qiang  DING Er-Run  HU Yu-Lai  YU Zhao-Wen  CHEN Li-Ren
Institution:ZHOU Zhi Qiang,DING Er Run,HU Yu Lai,YU Zhao Wen,CHEN Li Ren *
Abstract:In the present study, amylose tris(phenylcarbamate)(ATPC) and amylose tris(3,5 dimethylphenylcarbamate)(ADMPC) were synthesized, and used as the chiral stationary phases upon adsorption over silica gel. These stationary phases offered a practically useful chiral column with a high enantiomer separability. Amylose was allowed to react with an excess of phenylisocyanate or 3,5 dimethylphenylisocyanate in pyridine for 48 h. The carbamates obtained were dissolved and adsorbed on silica gel which had been treated with 3 aminopropyltriethoxysilane. The weight ratio of the carbamate to the silica gel was 0 45/2 55. The eight thio glycidyl ethers were resolved on the two chiral stationary phases. Separation was carried out with a hexane/2 propanol mixture at a flow rate of 1.0 mL/min at room temperature. The effects of chiral stationary phases and 2 propanol concentration on the retention and resolution were investigated.
Keywords:HPLC  Amylose chiral stationary phase  Racemic thio glycidyl ether                        Enantiomeric separation  
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