| 新型喹唑啉酮衍生物的合成 |
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| 引用本文： | 唐健红,史大昕,王秀珍,刘璇,李加荣.新型喹唑啉酮衍生物的合成[J].高等学校化学学报,2012,33(3):501-506. |
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| 作者姓名： | 唐健红 史大昕 王秀珍 刘璇 李加荣 |
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| 作者单位： | 1. 北京理工大学化工与环境学院, 北京 100081;
2. 华侨大学化工学院, 厦门 361021 |
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| 摘 要： | 以醛、 丙二腈和酮为起始原料, 在乙酸铵的催化下一锅合成了2,6-二氰基苯胺衍生物3, 化合物3在NaOH催化下, 与酮经过分子内Pinner反应到Dimroth重排组合转化, 得到新型多取代喹唑啉酮衍生物5. 化合物5的结构经IR, 1H NMR, 13C NMR和MS表征. 喹唑啉酮衍生物是一系列药物的重要中间体.
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| 关 键 词： | 丙二腈 2 6-二氰基苯胺衍生物 喹唑啉酮 环缩合 |
| 收稿时间： | 2011-04-25 |
Synthesis of Novel Quinazolinone Derivatives |
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| TANG Jian-Hong
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SHI Da-Xin
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WANG Xiu-Zhen
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LIU Xuan
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LI Jia-Rong.Synthesis of Novel Quinazolinone Derivatives[J].Chemical Research In Chinese Universities,2012,33(3):501-506. |
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| Authors: | TANG Jian-Hong SHI Da-Xin WANG Xiu-Zhen LIU Xuan LI Jia-Rong |
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| Institution: | 1. School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing 100081, China;
2. College of Chemical Engineering, Huaqiao University, Xiamen 361021, China |
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| Abstract: | 2,6-Dicyanoaniline derivatives(3) were synthesized from the multi-component condensation of aldehyde,malononitrile and ketone under the catalysis of ammonium acetate.Then 2,6-dicyanoaniline derivatives reacted with ketones to give mutli-substituted quinazolinone derivatives(5) using sodium hydroxide as catalyst at 100 ℃ or refluxing through intermolecule Pinner reaction via Dimroth rearrangement.The structures of the synthetic compounds were characterized by IR,1H NMR,13C NMR and MS.Quinazolinone derivatives are the important inter-mediate of a series of drugs. |
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| Keywords: | Malononitrile 2 6-Dicyanoaniline derivative Quinazolinone Cyclocondensation |
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