| 一种新型磁共振成像造影剂的制备及性能 |
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| 引用本文： | 杨晓露,杨兴旺,黄燕,张岐,吴静波,曹本男,张小燕.一种新型磁共振成像造影剂的制备及性能[J].高等学校化学学报,2012,33(2):426-429. |
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| 作者姓名： | 杨晓露 杨兴旺 黄燕 张岐 吴静波 曹本男 张小燕 |
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| 作者单位： | 1. 江苏大学化学化工学院, 镇江 212013;
2. 海南大学海南精细化工重点实验室, 海口 570228 |
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| 基金项目： | 国家自然科学基金，江苏省科技支撑计划，海南大学奖励基金，海南省自然科学基金，江苏大学学生科研立项 |
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| 摘 要： | 通过酰化反应将窄分子量分布的低聚壳聚糖(CSn, n＝6, 8, 11)引入到二乙三胺五乙酸(DTPA)中得到新型配体, 再与Mn2+配位得到3种顺磁性Mn(Ⅱ)基配合物, 其结构用IR、元素分析及电感耦合等离子体发射仪(ICP-AES)进行表征. 测定了配合物的纵向弛豫率(r1), 结果表明, 这类造影剂的弛豫率高于商业化医用的磁共振成像对比剂Gd-DTPA. 通过等温滴定微量热法(ITC)测定了功能配合物与牛血清白蛋白(BSA)相互作用的热力学参数.
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| 关 键 词： | 造影剂 壳聚糖 弛豫率 等温滴定微量热(ITC) |
| 收稿时间： | 2011-03-01 |
Synthesis and Properties of a Novel Contrast Agent |
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| YANG Xiao-Lu
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YANG Xing-Wang
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HUANG Yan
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ZHANG Qi
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WU Jing-Bo
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CAO Ben-Nan
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ZHANG Xiao-Yan.Synthesis and Properties of a Novel Contrast Agent[J].Chemical Research In Chinese Universities,2012,33(2):426-429. |
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| Authors: | YANG Xiao-Lu YANG Xing-Wang HUANG Yan ZHANG Qi WU Jing-Bo CAO Ben-Nan ZHANG Xiao-Yan |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China;
2. Hainan University, Hainan Provincial Key Lab of Fine Chemicals, Haikou 570228, China |
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| Abstract: | Chitosan oligosaccharides(CSn,n=6,8,11) with narrow molecular weight distribution and low polymerization degree were introduced into diethylenetriamine pentaacetic(DTPA) by acylation reaction.The synthesized novel ligands were coordinated to Mn2+,then the paramagnetic Mn2+-based complexes were gained.The structures of synthesized ligands and the corresponding complexes were characterized by IR,elemental analysis,and ICP-AES.The longitudinal relaxivities(r1) were measured.The results show that r1 of Mn-DTPA-CSn are higher than that of commercial contrast agent Gd-DTPA.Besides,the thermodynamical parameters of the interaction between the functional complexes and bovine serum albumin(BSA) were conducted by isothermal titration calorimetry(ITC). |
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| Keywords: | Contrast agent Chitosan Relaxivity Isothemal titration calorimetry(ITC) |
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