含吡啶环拟除虫菊酯的合成及其杀虫杀螨活性

在新农药的创制中 ,吡啶作为苯环的生物等排体常被用作分子设计的有效基团 1,2 ] ,近年来若干含有吡啶环的高效农药如吡虫啉 (Imidacloprid) 3 ] 、盖草能 (Haloxyfop) 4 ] 、啶氧菌酯 (Picoxystrobin) 5]等已被开发应用 .为合成筛选高生物活性化合物 ,我们在前期研究6 ,7] 的基础上 ,将吡啶环引入拟除虫菊酯的酸部分 ,合成了与戊菊酯 (S- 5 4 3 9) 8] 和氰戊菊酯 (Fenvalerate) 8] 结构相近的新化合物 (5 ,6 ) ,并分离得到化合物 6的两对对映异构体 (α-和β-体 ) .生物活性测试表明 ,这些新化合物具有较高的杀虫或杀螨活性 .目标…

Synthesis and Insecticidal/Acaricidal Activities of New Pyrethroid Esters Containing Pyridine Ring

Preparations of new pyrethroid esters(5, 6) containing a pyridine ring in the acid moiety were described. The α and β form of α cyano 3 phenoxybenzyl esters 6 were separated chromato graphically. These compounds were screened for insecticidal activities against Mythimna separata(W.) and Aphis fabae and for miticidal activity against Tetranychus urticae. Compound 5 showed 85% mortality against Mythimna separata(W.) at 250 mg/L, and 6 β had more miticidal activity on Tetranychus urticae than fenvalerate at a mass fraction of 200 mg/L.