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| 高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物 | |
| 引用本文： | 苏强,刘清飞,梁琼麟,王义明,毕开顺,刘伟平,罗国安.高效液相色谱-电喷雾质谱(HPLC-ESI-MS/MS)测定新型抗癌铂配合物[J].高等学校化学学报,2007,28(8):1486-1488. |
| 作者姓名： | 苏强 刘清飞 梁琼麟 王义明 毕开顺 刘伟平 罗国安 |
| 作者单位： | 1. 沈阳药科大学药学院,沈阳,110016;清华大学生命科学与医学研究院,北京,100084 2. 清华大学生命科学与医学研究院,北京,100084 3. 清华大学化学系,北京,100084 4. 清华大学生命科学与医学研究院,北京,100084;清华大学化学系,北京,100084 5. 沈阳药科大学药学院,沈阳,110016 6. 昆明贵金属研究所,昆明,650221 |
| 基金项目： | 清华大学裕元医学研究基金 |
| 摘 要： | 采用高效液相色谱-电喷雾-多级质谱法(HPLC-ESI-MS/MS), 研究了cis-3,5-diisopropylsalylic cyclohexanodiaminoplatinum(Ⅱ)的电喷雾质谱行为, 鉴定了其杂质, 并测定了其纯度. |
| 关 键 词： | 电喷雾质谱 铂配合物 抗癌药物 |
| 文章编号： | 0251-0790（2007）08-1486-03 |
| 收稿时间： | 2006-11-23 |
| 修稿时间： | 2006-11-23 |
Application of HPLC-ESI-MS/MS to the Determination of a Novel Antitumour Platinum Complex |
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| SU Qiang,LIU Qing-Fei,LIANG Qiong-Lin,WANG Yi-Ming,BI Kai-Shun,LIU Wei-Ping,LUO Guo-An.Application of HPLC-ESI-MS/MS to the Determination of a Novel Antitumour Platinum Complex[J].Chemical Research In Chinese Universities,2007,28(8):1486-1488. | |
| Authors: | SU Qiang LIU Qing-Fei LIANG Qiong-Lin WANG Yi-Ming BI Kai-Shun LIU Wei-Ping LUO Guo-An |
| Institution: | 1. School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Institute of Life Science and Biomedicine, 3. Department of Chemistry, Tsinghua University, Beijing 100084, China; 4. Kunming Institute of Precious Metals, Kunming 650221, China |
| Abstract: | A novel platinum complex,named as saliplatin,was designed,synthesized and characterized with element analysis,coupled inductively plasma-mass spectrum,gravitational thermal-differential thermal analysis,ultraviolet-visible absorption spectrum,infrared spectrum,fast atom bombment mass spectrum and 1H NMR,etc.Its purity was investigated and determined.HPLC-ESI-MS was employed to separate the platinum complex and the impurity,and to identify and quantify the latter.It proved that the impurity in this novel compound was 3,5-diisopropylsalycilic acid,a reactant used in the synthesis of the novel platinum complex,identified with ESI-MS.The mass fraction was determined with HPLC as 4.3%,which meant that the purity of this new substance was 95.7%. |
| Keywords: | ESI-MS Platinum complex Antitumour drug |
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