316L钢表面纳米银镀层的制备、性质及血液相容性

采用恒电位电沉积方法在316L不锈钢表面沉积银纳米镀层, 并将钢板置于全氟硅烷溶液中浸泡, 通过动态凝血实验、 抗凝血时间测定、 血小板黏附实验、 溶血实验和蛋白吸附实验等手段, 测试材料的血液相容性. 结果表明, 通过上述方法可明显改善316L不锈钢的血液相容性, 而抗凝血性能、 溶血率及纤维蛋白吸附量不亚于裸钢板. 与316L裸不锈钢相比, 银镀膜全氟硅烷浸泡316L不锈钢具有良好的血液相容性, 是一种比较理想的冠状动脉支架材料, 具有良好的应用前景.

Preparation, Property and Blood Compatibility of Nanometer Silver Plating on 316L Steel Surface

Ag nanoparticles films were prepared by electrodeposition. The thin films were then treated with a avantin solution of 1H, 1H, 2H, 2H-perfluorooctyl triethoxysilane (25%, volume fraction) for 20 h. After these solution, 316L stainless steel’s surface mircoscopic view changed, so the hydrophobicity and oleophobic property were improved. The blood compatibility effect of the films was tested by dynamic blood coagulation experiment, anticoagulant time measurement, platelet adhesion experiment, hemolysis test, Protein adsorption experiment. As a result, platelet adsorption amount, activity level, albumin absorption amount have improved a lot by the nanometer silver plating on 316L steel surface, other index is similar with the bare steel. Nanometer silver plating on 316L steel surface can improve the blood compatibility of 316L steel. Compared with bare 316L stainless steel, Ag nanoparticles films has a better blood compatibility, it’s a appropriate material for coronary artery stent.