| 短肽5－氟尿嘧啶前体药物的合成及其抗肿瘤活性研究 |
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| 引用本文： | 罗毅,卓仁禧,范昌烈.短肽5－氟尿嘧啶前体药物的合成及其抗肿瘤活性研究[J].高等学校化学学报,1994,15(4):545. |
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| 作者姓名： | 罗毅 卓仁禧 范昌烈 |
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| 作者单位： | 武汉大学化学系, 武汉, 430072 |
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| 摘 要： | 短肽５－氟尿嘧啶前体药物的合成及其抗肿瘤活性研究罗毅，卓仁禧，范昌烈（武汉大学化学系，武汉，４３００７２）关键词氨基酸，短肽，５－氟尿嘧啶，抗肿瘤活性５－氟尿嘧啶（５－ＦＵ）是一种治疗癌症的广谱性抗代谢药物，但由于其毒副作用较大，从而限制了它在临床上...
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| 关 键 词： | 氨基酸 短肽 5－氟尿嘧啶 抗肿瘤活性 |
| 收稿时间： | 1993-05-15 |
Synthesis and Antitumor Activity of Peptidyl-N1-Hydroxymethyl-5-Fluorouracil |
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| LUO Yi,ZHUO Ren-Xi,FAN Chang-Lie.Synthesis and Antitumor Activity of Peptidyl-N1-Hydroxymethyl-5-Fluorouracil[J].Chemical Research In Chinese Universities,1994,15(4):545. |
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| Authors: | LUO Yi ZHUO Ren-Xi FAN Chang-Lie |
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| Institution: | Department of Chemistry, Wuhan University, Wuhan, 430072 |
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| Abstract: | Six hydrophobic peptidyl 5-FUprodrugs and four amino acid derivatives of 5-FU (Val, Leu, Phe, Gly) were synthesized.All of these new compounds were characterized by UV, IR,1H NMR and elementary analysis.The antitumor activity of these compounds were tested against EACcells in vitro. |
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| Keywords: | Amino acids Oligopeptide 5-Fluorouracil Antitumor activity |
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