| 核磁共振代谢组学数据的尺度归一化新方法 |
| |
| 引用本文： | 董继扬,李伟,邓伶莉,许晶晶,Julian L.Griffin,陈忠.核磁共振代谢组学数据的尺度归一化新方法[J].高等学校化学学报,2011,32(2):262-268. |
| |
| 作者姓名： | 董继扬 李伟 邓伶莉 许晶晶 Julian L.Griffin 陈忠 |
| |
| 作者单位： | 厦门大学物理系福建省等离子体与磁共振研究重点实验室;Department of Biochemistry;University of Cambridge;Cambridge CB2 1GA; |
| |
| 基金项目： | 国家卫生部科学研究基金-福建省卫生教育联合攻关计划(批准号:WKJ2008-2-36); 福建省自然科学基金(批准号:2009J01299)资助 |
| |
| 摘 要： | 提出了一种新的尺度归一化方法,该方法不强调各变量在尺度上的归一,而是在原始数据的基础上,通过提高稳定性高且在不同类别样本中具有显著差异性的变量的权重,以增强与特征代谢物相关的信息.分别采用模拟数据和真实代谢组学数据对新归一化方法的性能进行评估,并与单位方差法(Unit variance)、变量稳定性(Variable ...
|
| 关 键 词： | 尺度归一化 核磁共振 代谢组学 特征代谢物 |
| 收稿时间： | 2010-05-19 |
New Variable Scaling Method for NMR-based Metabolomics Data Analysis |
| |
| DONG ji-Yang,LI Wei,DENG Ling-Li,XU Jing-Jing,Julian L.Griffin,CHEN Zhong.New Variable Scaling Method for NMR-based Metabolomics Data Analysis[J].Chemical Research In Chinese Universities,2011,32(2):262-268. |
| |
| Authors: | DONG ji-Yang LI Wei DENG Ling-Li XU Jing-Jing Julian LGriffin CHEN Zhong |
| |
| Institution: | DONG Ji-Yang{1,2},LI Wei1,DENG Ling-Li1,XU Jing-Jing1,Julian L.Griffin2,CHEN Zhong{1}(1.Fujian Key Laboratory of Plasma and Magnetic Resonance,Department of Physics,Xiamen University,Xiamen 361005,China,2.Department of Biochemistry,University of Cambridge,Cambridge CB2 1GA,UK) |
| |
| Abstract: | Variable scaling is an important data pre-processing step in NMR metabolomics,especially for biomarkers identification.It aims to make the subsequent multivariate analysis more reliable and easier by highlighting the biomarkers-related variables,and reducing the contamination of the noise and irrelevant variables.A new scaling method is proposed in this paper.The proposed method adjusts the weight of variables by their significance and stabilities in order to enhance the variable probably related to signatu... |
| |
| Keywords: | Variable scaling NMR Metabolomics Signature metabolite |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
| 点击此处可从《高等学校化学学报》下载免费的PDF全文 |
|
