| 血液灌流用内毒素吸附材料研究 |
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| 引用本文： | 俞玫,王慧彦,刘涛,袁直.血液灌流用内毒素吸附材料研究[J].高等学校化学学报,2004,25(8):1465-1467. |
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| 作者姓名： | 俞玫 王慧彦 刘涛 袁直 |
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| 作者单位： | 南开大学高分子化学研究所, 吸附分离功能高分子材料国家重点实验室, 天津300071 |
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| 基金项目： | 国家“九七三”计划(批准号 :G19990 64 70 7)，国家自然科学基金(批准号:5 0 3 73 0 2 1)，教育部博士学科点基金 (批准号 :2 0 0 3 0 0 5 5 0 3 8)，南开大学科技创新基金资助 |
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| 摘 要： | 内毒素血症是败血症致死率极高的主要原因之一，迅速并有效地清除患者体内的内毒素，是临床医学面临的一个难题．用血液灌流的方法，选用有效的吸附剂，通过体外循环从血液中直接清除内毒素，受到了人们越来越多的关注．国内外研究者已开始研究利用该方法治疗内毒素血症，用活性炭
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| 关 键 词： | 内毒素 吸附 血液灌流 |
| 文章编号： | 0251-0790(2004)08-1465-03 |
| 收稿时间： | 2003-08-24 |
Hemperfusion Adsorbents Used in the Removing of Endotoxin |
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| YU Mei,WANG Hui-Yan,LIU Tao,YUAN Zhi.Hemperfusion Adsorbents Used in the Removing of Endotoxin[J].Chemical Research In Chinese Universities,2004,25(8):1465-1467. |
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| Authors: | YU Mei WANG Hui-Yan LIU Tao YUAN Zhi |
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| Institution: | State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | A series of modified poly(methyl methacrylate) adsorbents were prepared and their adsorption abilities to endotoxin,which is a component of the outer membrance of Gram-negative bacteria,were compared. The results showed that the adsorbent modified by dimethylamine ligand with a long spacer had the best capacity for adsorbing endotoxin. The adsorbent P-N4,having a hydroxyl group at β -site of the ligand,could form the hydrogen bond with phosphate group. The electrostatic interaction,hydrogen bond and cooperative effect of octatomic ring worked simultaneously. All these factors are responsible for the strong interactions between endotoxin molecule and the adsorbent. |
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| Keywords: | Endotoxin Adsorption Hemoperfusion |
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