| 水杨酸键联卟啉的合成及与牛血清白蛋白的相互作用 |
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| 引用本文： | 贾涛,王凯,鲍小平,赵一玫,李早英.水杨酸键联卟啉的合成及与牛血清白蛋白的相互作用[J].高等学校化学学报,2004,25(9):1604-1607. |
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| 作者姓名： | 贾涛 王凯 鲍小平 赵一玫 李早英 |
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| 作者单位： | 1. 武汉大学化学与分子科学学院, 武汉430072;
2. 武汉化工学院化工与制药系, 武汉430074;
3. 红桃K集团股份有限公司研究院, 武汉430070 |
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| 基金项目： | 国家自然科学基金 (批准号 :2 9972 0 3 5 )，武汉大学自强科学基金 ( 2 0 0 0年 )资助 |
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| 摘 要： | 以溴代烷氧基苯基卟啉(1)为原料与水杨酸作用,分别得到了化合物2和3,再与醋酸钴反应,得到了钴卟啉配合物4和5.新化合物分别由1HNMR,IR,UV-Vis,MS和元素分析确证.同时,利用荧光光谱考察了金属卟啉与牛血清白蛋白的相互作用.
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| 关 键 词： | 金属卟啉 水杨酸 合成 牛血清白蛋白 荧光光谱 |
| 文章编号： | 0251-0790(2004)09-1604-04 |
| 收稿时间： | 2003-11-11 |
Synthesis of Metal Porphyrins Bonded with Salicylic Acid and Their Interaction with Bovine Serum Albumin |
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| JIA Tao,WANG Kai ,BAO Xiao-Ping,ZHAO Yi-Mei,LI Zao-Ying.Synthesis of Metal Porphyrins Bonded with Salicylic Acid and Their Interaction with Bovine Serum Albumin[J].Chemical Research In Chinese Universities,2004,25(9):1604-1607. |
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| Authors: | JIA Tao WANG Kai BAO Xiao-Ping ZHAO Yi-Mei LI Zao-Ying |
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| Institution: | 1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China;
2. Department of Pharmaceutical Technology, Wuhan Institute of Chemical Techology, Wuhan 430074, China;
3. Institute of RHK(Group) Co. Ltd., Wuhan 430070, China |
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| Abstract: | A synthetic method of porphyrins bonded with salicylic substituents was described. Reaction of bromoalkoxyphenyl porphyrin(1) with salicylic acid gave free porphyrins 2 and 3. Treatment of porphyrins 2 and 3 with Co(OCOCH 3) 2 respectively, afforded metalloporphyrins 4 and 5. These new compounds were confirmed by 1H NMR, IR, UV-Vis, MS and elemental analysis, and their interaction with bovine serum albumin(BSA) in fluorescence spectrum was observed. |
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| Keywords: | Metalloporphyrin Salicylic acid Synthesis Bovine serum albumin(BSA) Fluorescence spectrum |
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