|
|||||
|
|
| 素食人群尿液1H NMR代谢轮廓的多因素方差分析 | |
| 引用本文： | 董继扬,邓伶莉,CHENG Kian-Kai,陈忠.素食人群尿液1H NMR代谢轮廓的多因素方差分析[J].高等学校化学学报,2011,32(12):2769-2776. |
| 作者姓名： | 董继扬 邓伶莉 CHENG Kian-Kai 陈忠 |
| 作者单位： | 1. 厦门大学电子科学系,福建省等离子体与磁共振研究重点实验室,厦门361005;Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK 2. 厦门大学电子科学系,福建省等离子体与磁共振研究重点实验室,厦门361005 3. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK;Department of Bioprocess Engineering, Universiti Teknologi Malaysia, Skudai 81310, Malaysia 4. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK |
| 基金项目： | 国家自然科学基金，中央高校基本科研业务费专项资金 |
| 摘 要： | 结合方差分析(ANOVA)和偏最小二乘法判别分析(PLS-DA)两种分析技术,对素食和普食人群的尿液1H NMR谱进行分析.利用ANOVA方法将数据矩阵分解为几个独立因素矩阵,滤除干扰因素后,再利用PLS-DA对单因素数据进行建模分析.实验结果表明,ANOVA/PLS-DA方法可以有效地减少饮食因素和性别因素之间的相互... |
| 关 键 词： | 多因素分析 方差分析 偏最小二乘法判别分析 核磁共振代谢组学 |
| 收稿时间： | 2010-12-07 |
Investigation of 1H NMR Profile of Vegetarian Human Urine Using ANOVA-based Multi-factor Analysis |
|
| DONG Ji-Yang,DENG Ling-Li,CHENG Kian-Kai,GRIFFIN Julian L.,CHEN Zhong.Investigation of 1H NMR Profile of Vegetarian Human Urine Using ANOVA-based Multi-factor Analysis[J].Chemical Research In Chinese Universities,2011,32(12):2769-2776. | |
| Authors: | DONG Ji-Yang DENG Ling-Li CHENG Kian-Kai GRIFFIN Julian L CHEN Zhong |
| Institution: | 1. Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen Universitty, Xiamen 361005, China; 2. Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; 3. Department of Bioprocess Engineering, University of Technology Malaysia, Skudai 81310, Malaysia |
| Abstract: | In this study, a technique that combined both analysis of variance(ANOVA) and partial least squares-discriminant analysis(PLS-DA) was used to compare the urine 1H NMR spectra of healthy people from a vegetarian and omnivorous population. In ANOVA/PLS-DA, the variation in data was first decomposed into different variance components that each contains a single source of variation. Each of the resulting variance components was then analyzed using PLS-DA. The experimental results showed that ANOVA/PLS-DA is efficient in disentangling the effect of diet and gender on the metabolic profile, and the method could be used to extract biologically relevant information for result interpretation. |
| Keywords: | Multi-factor analysis Analysis of variance(ANOVA) Partial least squares-discriminant analysis(PLS-DA) NMR-based metabolomic |
| 本文献已被 万方数据 等数据库收录！ | |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 | |
| 点击此处可从《高等学校化学学报》下载免费的PDF全文 | |