| 框架核酸辅助的仿生膜构建 |
| |
| 引用本文： | 严磊,毛秀海,左小磊.框架核酸辅助的仿生膜构建[J].高等学校化学学报,2020,41(7):1415. |
| |
| 作者姓名： | 严磊 毛秀海 左小磊 |
| |
| 作者单位： | 上海交通大学医学院附属仁济医院分子医学研究院, 上海市核酸化学与纳米医学重点实验室, 上海 200127 |
| |
| 基金项目： | 国家自然科学基金(21804088);上海交通大学医学院高水平地方高校创新团队(SSMU-ZLXX20180701);上海交通大学医学院高峰学科-“临床专职科研队伍”(20171913);上海市教育发展基金会和教育委员会“曙光计划”(18SG16) |
| |
| 摘 要： | 仿生膜的构建有利于了解并掌握生物膜的功能及其机理, 同时对其在生命医学及疾病诊断等相关领域的应用具有重要意义. 以框架核酸为组装单元, 构建新型仿生膜材料是一种有效且具有发展前景的方法和研究方向. 本文综述了框架核酸的设计、 制备与表征, 总结了框架核酸修饰到脂质膜上的方式. 同时, 对框架核酸辅助的仿生膜的应用情况进行了阐述, 并探讨了框架核酸在仿生膜研究领域所面临的机遇与挑战.
|
| 关 键 词： | 生物仿生 细胞膜 框架核酸 DNA纳米技术 |
| 收稿时间： | 2020-05-06 |
Biomimicry of Cellular Membrane with Framework Nucleic Acids† |
| |
| YAN Lei,MAO Xiuhai,ZUO Xiaolei.Biomimicry of Cellular Membrane with Framework Nucleic Acids†[J].Chemical Research In Chinese Universities,2020,41(7):1415. |
| |
| Authors: | YAN Lei MAO Xiuhai ZUO Xiaolei |
| |
| Institution: | Institute of Molecular Medicine, Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China |
| |
| Abstract: | Biomimicry of cellular membrane is crucial for the study of cellular communications and transportation, and holds great potentials in various applications, including nanomedicine, nanopore based single molecule detection, cell imaging, drug delivery and cancer therapy. Owing to its ability to nanoscale precisely shape and manipulation, construction of framework nuclei acids(FNAs) provides a promising approach to bio-mimicking cellular membrane proteins and exploiting their functions and applications. In this review, we introduce the structure and imaging technology for FNAs as well as assembling methods for FNAs based artificial cellular membrane in recent years. In addition, the application fields as well as the existing opportunities and challenges of FNAs based biomimicry of cellular membrane are discussed. |
| |
| Keywords: | Biomimicry Cellular membrane Framework nucleic acid DNA nanotechnology |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《高等学校化学学报》浏览原始摘要信息 |
| 点击此处可从《高等学校化学学报》下载免费的PDF全文 |
|
