1-(4-氯苯基)-2-环丙基酮肟醚的设计、 合成及杀虫活性

采用中间体衍生化方法, 以环唑醇中间体1-(4-氯苯基)-2-环丙基丙酮作为基本骨架, 引入肟醚活性片段, 合成了32个新的1-(4-氯苯基)-2-环丙基酮肟醚类化合物, 其化学结构经核磁共振波谱和质谱等确认. 单晶X衍射分析表明, 化合物2n属于单斜晶系, 空间群为P2₁/c. 生物活性筛选结果表明, 化合物1i在200 mg/L浓度下对蚜虫的致死率为78.57%; 化合物1g在200 mg/L浓度下对红蜘蛛的致死率为69.95%; 化合物1i在200和12.5 mg/L浓度下对黏虫的致死率分别为100%和85%.

Design,Synthesis and Insecticidal Activity of 1-(4-Chlorophenyl)-2-cyclopropylpropan-1-one Oxime Ether †

Based on the intermediate derivatization method, the active fragment of oxime ether was introduced into 1-(4-chlorophenyl)-2-cyclopropylpropan-1-one as a basic skeleton, and 32 novel compounds were designed and synthesized with the fragment of 1-(4-chlorophenyl)-2-cyclopropylpropan-1-one. Their chemical structures were confirmed by nuclear magnetic resonance spectroscopy and mass spectrometry. Single crystal X-ray diffraction of compound 2n was carried out. The result showed that compound 2n belonged to the monoclinic system and space group of 2n was P2₁/c. The initial screening activity showed that the mortality rate of compound 1i and 1g against aphids and red spiders were 78.57% and 69.95% at the concentration of 200 mg/L, respectiviely, while the mortality rate of compound 1i were 100% and 85% against aphids at the concentration of 200 and 12.5 mg/L, respectiviely. The results showed that compound 1i had the value of further development.