| 氨基酸5-氟尿嘧啶酯类衍生物的合成及其抗肿瘤活性研究 |
| |
| 引用本文： | 赵儒林,范昌烈,卓仁禧.氨基酸5-氟尿嘧啶酯类衍生物的合成及其抗肿瘤活性研究[J].高等学校化学学报,1989(6). |
| |
| 作者姓名： | 赵儒林 范昌烈 卓仁禧 |
| |
| 作者单位： | 武汉大学化学系
(赵儒林，范昌烈)，武汉大学化学系(卓仁禧) |
| |
| 摘 要： | 以N-保护的氨基酸钾盐与1-(ω-溴丙基)-5-氟尿嘧啶和1-(ω-溴丁基)-5-氟尿嘧啶反应,制备了18种氨基酸的ω-(N~1-5-氟尿嘧啶基)-丙醇酯和丁醇酯的盐酸盐,并确定了它们的结构。动物试验的初步结果表明,酪氨酸、苯丙氨酸的3-(N~1-5-氟尿嘧啶基)-丙醇酯盐酸盐对小鼠艾氏腹水癌的抑制率分别为88.1％和86.7％。
|
| 关 键 词： | 5-氟尿嘧啶 氨基酸 抗肿瘤活性 |
Synthesis of Amino Acid 5-Fluorouracil Esters Derivatives and Study on Their Antitumor Activity |
| |
| Zhao Rulin,Fan Changlie,Zhuo Renxi.Synthesis of Amino Acid 5-Fluorouracil Esters Derivatives and Study on Their Antitumor Activity[J].Chemical Research In Chinese Universities,1989(6). |
| |
| Authors: | Zhao Rulin Fan Changlie Zhuo Renxi |
| |
| Abstract: | Eighteen amino acid 5-fluoroiu-acil-propyl(butyl) ester hydrochlorides were synthesized by the reaction of N-protected salts of amino acids with 1-(w-bromopropyl)-5-fluorouracil and 1-(w-bromobutyl)-5-fluorouracil in DMF. The structures of these new compounds were characterized by 1H NMR, IR and UV spectra, as well as elemental analysis, Tyrosine and phenylalanine 5-fluorouracil-propyl ester hydrochlorides show an inhibition ratio of 88.1% and 86.7% respectively against Ehrlich Ascites Carcinoma in mice. |
| |
| Keywords: | 5-Fluorouracil Amino acid Antitumor activity |
| 本文献已被 CNKI 等数据库收录！ |
