Ab Initio and MNDO Calculation of the Intermediates of N-Diisopropylphosphoryl L-lspartic Acid |
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Authors: | CHEN Zhong-Zhou TAN Bo LI Yan-Mei ZHAO Yu-Fen |
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Institution: | Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100084 |
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Abstract: | Many biological processes are regulated by the phosphorylation and dephosphorylation of amino acid residues in the proteins1]. High-coordinate phosphorus intermediates forming from amino acid residues in protein are of great importance in the process of phosphorylation and dephosphorylation of protein. It has been proposed that the mechanisms of phosphorylation through penta-coordinate intramolecular mixed carboxylic-phosphoric anhydride intermediates2]. It was found that α-COOH group3] and β-COOH group4] in aspartic acid had different activities in the ester exchange on phosphorus. So it is important to discuss which carboxylic acids is involved in the penta-coordinate phosphorus intermediate of aspartic acid. |
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