| 海藻酸钠-壳聚糖微胶囊膜强度的研究 |
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| 引用本文： | 刘群,薛伟明,于炜婷,刘袖洞,严若媛,李金云,马小军.海藻酸钠-壳聚糖微胶囊膜强度的研究[J].高等学校化学学报,2002,23(7):1417-1420. |
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| 作者姓名： | 刘群 薛伟明 于炜婷 刘袖洞 严若媛 李金云 马小军 |
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| 作者单位： | 中国科学院大连化学物理研究所,大连,116023 |
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| 基金项目： | 国家自然科学基金项目 (批准号 :2 990 60 11) |
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| 摘 要： | 以乳化／内部凝胶化法制备了海藻酸钠－壳聚糖微胶囊，重点考察了成膜反应过程中影响微胶囊膜强度的几个主要参数，实验发现，壳聚糖分子量低于100000，成膜反应时间高于15min，壳聚糖溶液pH值在6.0左右时制备的微胶囊膜强度较高，初步探讨了海藻酸钠与壳聚糖两种高分子发生聚电解质络合反应的机制。
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| 关 键 词： | 微胶囊膜 强度 海藻酸钠 壳聚糖 内部凝胶化 药物载体 药物控释 |
| 文章编号： | 0251-0790(2002)07-1417-04 |
Studies on the Membrane Strength of Alginate/Chitosan Microcapsule Prepared by Emulsification/Internal Gelation Method |
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| LIU Qun,XUE Wei Ming,YU Wei Ting,LIU Xiu Dong,YAN Ruo Yuan,LI Jin Yun,MA Xiao Jun.Studies on the Membrane Strength of Alginate/Chitosan Microcapsule Prepared by Emulsification/Internal Gelation Method[J].Chemical Research In Chinese Universities,2002,23(7):1417-1420. |
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| Authors: | LIU Qun XUE Wei Ming YU Wei Ting LIU Xiu Dong YAN Ruo Yuan LI Jin Yun MA Xiao Jun |
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| Institution: | LIU Qun,XUE Wei Ming,YU Wei Ting,LIU Xiu Dong,YAN Ruo Yuan,LI Jin Yun,MA Xiao Jun * |
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| Abstract: | The alginate/chitosan microcapsule was prepared by emulsification/internal gelation method. It was found that the membrane strength was significantly affected by the molecular weight of chitosan, reaction time of these two polymers and the pH value of chitosan solution. When the molecular weight of chitosan was lower than 0.1 million, reaction time was higher than 15 min, pH of chitosan solution was about 6.0, then the most strongest membrane was obtained. At the same time the principle of the reaction of polyelectrolyte complexation was investigated. |
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| Keywords: | Alginate Chitosan Microcapsule Emulsification Internal gelation |
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