| 新颖的蛋白质格点模型 |
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| 引用本文： | 章林溪,赵得禄.新颖的蛋白质格点模型[J].高等学校化学学报,2001,22(7):1241-1243. |
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| 作者姓名： | 章林溪 赵得禄 |
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| 作者单位： | 1. 浙江大学物理系, 杭州 310028;
2. 中国科学院化学研究所分子科学中心, 北京 100080 |
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| 基金项目： | 国家自然科学基金 (批准号 :198740 2 1)，国家重点基础研究专项经费 (批准号 :95 -预 -12和 G19990 6 480 0 ) |
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| 摘 要： | 提出了建立在键长涨落模型基础上的蛋白质格点模型,通过对二维蛋白质分子的构象研究,发现这种蛋白质分子具有更多的紧密接触对、更低的基态能量和更大的平均紧密度.蛋白质分子的构象数与键数目N的关系为:Ω0～γN,这里γ=4.768.同时与二维的正方形蛋白质格点模型进行了比较.
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| 关 键 词： | 蛋白质分子 键长涨落模型 构象 紧密接触对 |
| 文章编号： | 0251-0790(2001)07-1241-03 |
| 收稿时间： | 2000-08-02 |
A New Protein Lattice Model |
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| ZHANG Lin-Xi,ZHAO De-Lu.A New Protein Lattice Model[J].Chemical Research In Chinese Universities,2001,22(7):1241-1243. |
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| Authors: | ZHANG Lin-Xi ZHAO De-Lu |
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| Institution: | 1. Department of Physics, Zhejiang University, Hangzhou 310028, China;
2. Polymer Physics Laboratory, Center of Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China |
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| Abstract: | Anew protein lattice model basing on the bond fluctuation model is performed in this paper. Through investigation of two-dimensional protein structure using our lattice model, we find that our two-dimensional protein chains have more contacts. The conformations Ω0 may be expressed as Ω0=γN, here Nis chain length and γ =4768, and the average compactness < ρ(N) > is close to 0.31-0.32. For the given HPsequences, our protein lattices have lower ground state energies. Comparisons with two-dimensional square lattice model are also made. |
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| Keywords: | Protein Bond fluctuation model Conformation Contact |
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