| 以壳聚糖为载体的内毒素吸附剂 |
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| 引用本文： | 王慧彦,侯光辉,俞玫,袁直,刘斌,赵承梅.以壳聚糖为载体的内毒素吸附剂[J].高等学校化学学报,2005,26(4):680-682. |
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| 作者姓名： | 王慧彦 侯光辉 俞玫 袁直 刘斌 赵承梅 |
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| 作者单位： | 吸附分离功能高分子材料国家重点实验室,南开大学高分子化学研究所,天津,300071;天津医学高等专科学校,天津,300052 |
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| 基金项目： | 国家重点基础研究发展计划(973计划);中国科学院资助项目;高等学校博士学科点专项科研项目;南开大学校科研和教改项目 |
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| 摘 要： | 内毒素血症(Endotoxemia)可出现于多种疾病过程中，导致器官坏死、不可逆休克和死亡。如何及时并有效地清除患者体内的内毒素，是临床医学面临的一个难题．选用高效吸附剂，籍助血液灌流的方法从血液中直接清除内毒素，受到了人们越来越多的关注。
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| 关 键 词： | 壳聚糖 内毒素 吸附剂 血液灌流 |
| 文章编号： | 0251-0790(2005)04-0680-03 |
Adsorbents for Endotoxin Based on Chitosan Matrix |
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| WANG Hui-Yan,HOU Guang-Hui,YU Mei,YUAN Zhi,LIU Bin,ZHAO Cheng-Mei.Adsorbents for Endotoxin Based on Chitosan Matrix[J].Chemical Research In Chinese Universities,2005,26(4):680-682. |
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| Authors: | WANG Hui-Yan HOU Guang-Hui YU Mei YUAN Zhi LIU Bin ZHAO Cheng-Mei |
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| Abstract: | The endotoxin adsorbents were prepared by coupling divinyl amine ligands on crosslinked chitosan matrix. Their adsorption ability to endotoxin was compared. It was found that the adsorbent with polyethylene polyamine ligand had the highest adsorption capacity and its clearance percent for endotoxin in endotoxemia plasma was over 80%. The results also showed that the adsorbent has good blood compatibility and clinical application foreground. |
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| Keywords: | Chitosan Endotoxin Adsorbent Hemoperfusion |
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