| 多碳醇类化合物的合成 |
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| 引用本文： | 杨石先,陈茹玉,刘准,陈金龙,王立坤,石国柱.多碳醇类化合物的合成[J].高等学校化学学报,1980,1(1):66. |
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| 作者姓名： | 杨石先 陈茹玉 刘准 陈金龙 王立坤 石国柱 |
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| 作者单位： | 南开大学元素有机化学研究所 |
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| 摘 要： | 本文由正-二十四烷酸与五氯化磷反应,得到的二十四烷酰氯在氯仿中和三乙胺存在下与1-吗啉-1-环己烯反应所得中间体,经酸性水解,碱性开环和酸化,得到7-氧代-三十烷酸,而据文献报导7],正-二十四烷酞氯与1-吗啉-1-环己烯反应结果,得到的仍然是原料二十四烷酸。作者采用上述方法合成了五种新的7-氧代烷酸R-C(=O)-(CH2)5-COOH(R=n-C14H29,n-C16H33,n-C18H37,n-C21H43和n-C23H47)。所制得的7-氧代三十烷酸经黄鸣龙改良的开息纳尔-武尔夫还原,再经四氢锂铝还原,即得三十烷醇。
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| 收稿时间： | 1979-11-18 |
SYNTHESIS OF HIGHER PRIMARY ALKANOLS |
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| Yang Shih-hsien,Chen Ju-yu,Liu Zhun,Chen Jinlong,Wang Likun,Shi Guozhu.SYNTHESIS OF HIGHER PRIMARY ALKANOLS[J].Chemical Research In Chinese Universities,1980,1(1):66. |
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| Authors: | Yang Shih-hsien Chen Ju-yu Liu Zhun Chen Jinlong Wang Likun Shi Guozhu |
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| Institution: | The Institute of Elemento-Organic Chemistry, Nankai University |
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| Abstract: | Five new 7-oxo-alkanoic acids,R-CO-(CH2)6-COOH (Where R=CH3-(CH2)13,CH3(CH2)15,CH3(CH2)17,CH3(CH2)20and CH3(CH2)32),have been prepared by the reaction of carboxylic chlorides with 1-morpholino -1-cyclohexene.The acids thus formed were reduced twice by first Huang-Minion modification of the Wolff-Kishner method and then lithium aluminum hydride,giving the corresponding higher primary alkanols.We studied the necessary conditions of the reaction of long chain acyl chlorides with 1-morpholino-l-cyclohexene in the presence of triethyl amine and successfully prepared the 7-oxo-alkanoic acids. |
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