| 表面增强拉曼光谱对西地那非类药物的快速检测 |
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| 引用本文： | 王红梅,李玲玲,陈海滨,曾勇明,陈宏炬,陈启振,林惠真,田中群,刘国坤.表面增强拉曼光谱对西地那非类药物的快速检测[J].高等学校化学学报,2017,38(6). |
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| 作者姓名： | 王红梅 李玲玲 陈海滨 曾勇明 陈宏炬 陈启振 林惠真 田中群 刘国坤 |
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| 作者单位： | 1. 厦门市食品药品质量检验研究院,厦门,361012;2. 厦门大学环境与生态学院,近海海洋环境科学国家重点实验室,厦门 361102;厦门市普识纳米科技有限公司,厦门361005;3. 厦门大学化学化工学院,厦门,361005;4. 厦门大学环境与生态学院,近海海洋环境科学国家重点实验室,厦门 361102 |
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| 基金项目： | 国家自然科学基金，福建省高校产学合作项目，中央高校基本科研业务费专项资金，the National Natural Science Foundation of China，the University-Industry Cooperation Foundation of Fujian Province |
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| 摘 要： | 采用表面增强拉曼光谱(SERS)技术并结合简单的前处理流程,对保健品样品中11种西地那非类药物进行了非定向快速筛查研究.结果表明,11种西地那非类药物可根据结构分为5类,类别之间SERS谱图差异显著;类别内SERS谱图具有共性特征,特征峰相对强度差异明显.实际样品的检测中,西地那非类药物的最低检出浓度约为0.05 mg/kg;前处理和测试的总时长约为3~5 min,且与检测目标物和样品无关.本方法高灵敏度、快速和非定向检测的设计理念为快速检测保健品中违禁添加药物提供了新思路和新方法.
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| 关 键 词： | 表面增强拉曼光谱 西地那非类药物 非定向快速检测 高灵敏度 |
Application of Surface-enhanced Raman Spectroscopy in the Fast Screening of Phosphodiesterase Type 5 Inhibitors |
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| WANG Hongmei,LI Lingling,CHEN Haibin,ZENG Yongming,CHEN Hongju,CHEN Qizhen,LIN Huizhen,TIAN Zhongqun,LIU Guokun.Application of Surface-enhanced Raman Spectroscopy in the Fast Screening of Phosphodiesterase Type 5 Inhibitors[J].Chemical Research In Chinese Universities,2017,38(6). |
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| Authors: | WANG Hongmei LI Lingling CHEN Haibin ZENG Yongming CHEN Hongju CHEN Qizhen LIN Huizhen TIAN Zhongqun LIU Guokun |
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| Abstract: | Aiming at the absence of a fast and effective screening technique facing the prevalence of the illegal adulterant of Phosphodiesterase type 5(PDE-5) inhibitor in health products, a non-designated detection platform based on surface-enhanced Raman spectroscopy(SERS) was proposed.Integrated with a simple pretreatment process in 3-5 min, SERS measurement was carried out on those suspicious health product samples with the lowest detectable concentration at a level of 0.05 mg/kg.The advantages of short time and high sensitivity satisfy the urgent demand of the fast screening and on-site inspection of the authorities. |
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| Keywords: | Surface-enhanced Raman spectroscopy Phosphodiesterase type 5(PDE-5) Non-targeting quick screening High sensitivity |
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