| 四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉的合成及结构表征 |
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| 引用本文： | 郭喜明,郭斌,陈业宏.四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉的合成及结构表征[J].高等学校化学学报,2013,34(3):499-502. |
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| 作者姓名： | 郭喜明 郭斌 陈业宏 |
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| 作者单位： | 1. 哈尔滨工业大学生命科学与技术学院,哈尔滨,150001
2. 哈尔滨工业大学材料工程学院,哈尔滨,150001 |
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| 基金项目： | 中央高校基本科研业务费专项基金(批准号:2010012,2009003);科技部国际合作项目(批准号:2012DFR203320)资助 |
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| 摘 要： | 设计并合成了一种卟啉类光敏剂与抗癌药羟基喜树碱通过共价键相连的四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉化合物.通过紫外光谱、红外光谱、核磁氢谱和质谱分析等手段对其结构进行了表征.在癌症治疗过程中目标化合物中2种药物可能起到一定的协同效应.
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| 关 键 词： | 卟啉 10-羟基喜树碱 四对氯乙酰氧基苯基卟啉 四(对-乙酰氧醚-10-羟基喜树碱)苯基卟啉 |
| 收稿时间： | 2012-11-02 |
Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin |
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| GUO Xi-Ming
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GUO Bin
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CHEN Ye-Hong.Synthesis and Character of Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin[J].Chemical Research In Chinese Universities,2013,34(3):499-502. |
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| Authors: | GUO Xi-Ming GUO Bin CHEN Ye-Hong |
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| Institution: | 1 (1.School of Life Science and Technology,2.Shool of Materials Scince and Engineering, Harbin Institute of Technology,Harbin 150001,China) |
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| Abstract: | Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin was designed and synthesized through tetrahydroxy-phenylporphyrin and 10-hydroxycamptothecin(HCPT). The structure of tetra(p-aceto-10-hydroxycamptothecin)phenyl porphyrin was confirmed by UV-Vis spectra, IR spectra, 1H NMR and MALDI-TOF-MS spectra. The mass spectra were measured under different conditions via MALDI-TOF-MS and Agilent LC-MS. Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin may play a synergistic effect in threapy of cancer. |
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| Keywords: | Porphyrin 10-Hydroxycamptothecin Tetra-p-chloroacetylphenylporphyrin" target="_blank">p-chloroacetylphenylporphyrin')" href="#">Tetra-p-chloroacetylphenylporphyrin Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin" target="_blank">p-aceto-10-hydroxycamptothecin)phenylporphyrin')" href="#">Tetra(p-aceto-10-hydroxycamptothecin)phenylporphyrin |
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