| 双萘酰亚胺衍生物用于检测水溶液中的苦味酸 |
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| 引用本文： | 赵永梅,穆叶舒,洪琛,罗稳,田智勇.双萘酰亚胺衍生物用于检测水溶液中的苦味酸[J].高等学校化学学报,2022,43(3):20210765-153. |
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| 作者姓名： | 赵永梅 穆叶舒 洪琛 罗稳 田智勇 |
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| 作者单位： | 1.河南应用技术职业学院制药工程学院, 开封 475004;2.河南大学药学院;3.天然药物与免疫工程重点实验室, 4. 淮河医院, 开封 475004 |
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| 基金项目： | 河南省科技计划项目;河南应用技术职业学院项目;国家自然科学基金 |
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| 摘 要： | 设计合成了一个新的双1,8-萘酰亚胺衍生物(Bis-Nph), 并通过核磁共振波谱和高分辨质谱鉴定了其结构. Bis-Nph呈现出典型的分子内电荷转移(ICT)和聚集诱导增强发射(AIEE). 该化合物可以作为荧光探针检测水溶液中的苦味酸(2,4,6-三硝基苯酚, TNP), 检出限为5.8×10-7 mol/L. 作用机制为TNP的质子转移到Bis-Nph, 有效地阻断了其ICT发射, 使荧光发生显著猝灭. 另外, Bis-Nph的细胞毒性较低, 可做成试纸进行TNP的快速检测.
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| 关 键 词： | 萘酰亚胺 荧光探针 聚集诱导增强发射 2 4 6-三硝基苯酚 |
| 收稿时间： | 2021-11-08 |
Bis-naphthalimide Derivatives for Picronitric Acid Detection in Aqueous Solution |
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| ZHAO Yongmei,MU Yeshu,HONG Chen,LUO Wen,TIAN Zhiyong.Bis-naphthalimide Derivatives for Picronitric Acid Detection in Aqueous Solution[J].Chemical Research In Chinese Universities,2022,43(3):20210765-153. |
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| Authors: | ZHAO Yongmei MU Yeshu HONG Chen LUO Wen TIAN Zhiyong |
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| Institution: | 1.Pharmaceutical Engineering Department，Henan Vocational College of Applied Technology，Kaifeng 475004，China;2.School of Pharmacy;3.Key Laboratory of Natural Medicine and Immuno?Engineering;4.Huaihe Hospital，Henan University，Kaifeng 475004，China |
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| Abstract: | A novel bis-naphthalimide derivative（Bis-Nph） was designed， synthesized and characterized by nuclear magnetic resonance spectroscopy（NMR） and high resolution mass spectrometry（HRMS）. Compound Bis-Nph presented typical intramolecular charge transfer（ICT） emission and aggregation-induced enhanced emission（AIEE）. It could be used as a fluorescent probe to detect 2，4，6-trinitrophenol（TNP） in aqueous solution， the calculated limit of detection is 5.8×10-7 mol/L. The mechanism for sensing TNP was investigated using 1H NMR. The proton transfers from TNP to Bis-Nph and blocks the ICT emission， and causes the fluorescence to be quenched remarkably. Further， Bis-Nph showed low cytotoxicity and could be made into test strips for rapid TNP detection. |
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| Keywords: | Naphthalimide Fluorescent probe Aggregation-induced enhanced emission 2 4 6-Trinitrophenol |
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