聚环氧乙烷-g-聚己内酯两亲性接枝共聚物的合成及药物释放行为

通过环氧丙醇(GL)与环氧乙烷(EO)的阴离子顺序开环聚合制备了水溶性嵌段共聚物PEO-b-PGL, 以PGL嵌段每个重复单元的侧羟基为引发点进一步引发ε-己内酯(CL)的开环聚合, 合成了结构规整的以聚环氧乙烷(PEO)为主链的两亲性接枝共聚物(PEO-b-PGL-g-PCL). 研究了PEO-b-PGL-g-PCL在水相中的自组装行为, 采用稳态荧光探针法测定了胶束的临界胶束浓度(cmc). 以疏水性药物阿霉素(DOX)为模型药物, 研究了两亲性接枝共聚物的化学组成对药物的扩散释放以及降解释放行为的影响.

Synthesis and Controlled Drug Release of Amphiphilic Graft Copolymers PEO-b-PGL-g-PCL

Water-soluble diblock copolymers PEO-b-PGL with well controlled composition were synthesized by sequential anionic ring-opening copolymerization of ethylene oxide (EO) and glycidol(GL). ε-Caprolactone (CL) was further initiated by the pendant hydroxyl group of each GL unit in PEO-b-PGL copolymer to synthesize amphiphilic graft copolymers PEO-b-PGL-g-PCL with well defined grafting architecture. The self-assembly behavior of PEO-b-PGL-g-PCL graft copolymers was investigated with pyrene as a probe for the determination of critical micelle concentrations(cmc). Meanwhile, doxorubicin as a model drug was encapsulated into PEO-b-PGL-g-PCL micelles, and its release behavior controlled by diffusion and enzymatic degradation was studied. The influences of composition and grafting structure in PEO-b-PGL-g-PCL copolymers on self-assembly, drug loading and release were discussed.