| N-甲基吡咯类聚酰胺的合成及其与DNA的相互作用 |
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| 引用本文： | 李钦玲,周江,刘丹,袁谷.N-甲基吡咯类聚酰胺的合成及其与DNA的相互作用[J].高等学校化学学报,2005,26(12):2267-2269. |
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| 作者姓名： | 李钦玲 周江 刘丹 袁谷 |
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| 作者单位： | 1.北京大学化学学院化学生物学系生物有机与分子工程教育部重点实验室,北京100871;
2.青海民族学院化学系,西宁810007 |
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| 摘 要： | 本研究主要是设计并合成了3个含有4个N-甲基吡咯的聚酰胺化合物(PyPyPyPyβDp,PyPyPyPyγDp, NO2PyPyPyPyβDp),并使用ESI-MS法研究了其与DNA的相互作用.
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| 关 键 词： | 聚酰胺 电喷雾离子化质谱 DNA识别 聚酰胺 电喷雾离子化质谱 DNA识别 |
| 文章编号： | 0251-0790（2005）12-2267-03 |
| 收稿时间： | 11 11 2004 12:00AM |
| 修稿时间： | 2004-11-11 |
Synthesis of Polyamides Containing N-Methylpyrrole Rings and Their Interaction with DNA |
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| LI Qin-Ling,ZHOU Jiang,LIU Dan,YUAN Gu.Synthesis of Polyamides Containing N-Methylpyrrole Rings and Their Interaction with DNA[J].Chemical Research In Chinese Universities,2005,26(12):2267-2269. |
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| Authors: | LI Qin-Ling ZHOU Jiang LIU Dan YUAN Gu |
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| Institution: | 1.Department of Chemical Biology,Key Laboratory of Bioorganic and Molecular Engineering of ;
Education Ministry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China;
2.Department of Chemistry,Qinghai University for Nationalities,Xining 810007,China |
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| Abstract: | Polyamides containing N-methylpyrrole and N-methylimidazole amino acids have attracted considerable attention from biological chemists because they can permeate living cell membrane and have the potential to control specific gene expression.In this article,three polyamides containing N-methylpyrrole rings were synthesized by the chloroform reaction and the DCC/HOBT coupling reaction,and the interaction between the polyamides and DNA was investigated by electrospray ionization mass spectroscopy.The results of the experiments indicate that the designed polyamides can effectively bind the target DNA,and ESI mass spectrometry is an excellent tool for the analysis of the interactions between DNA and the polyamides. |
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| Keywords: | Polyamides Electrospray ionization mass spectroscopy DNA recognition |
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