| N-（O,O-二异丙基）磷酰化丝氨酸成肽反应的立体效应研究 |
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| 引用本文： | 胡建军,巨勇,赵玉芬.N-（O,O-二异丙基）磷酰化丝氨酸成肽反应的立体效应研究[J].高等学校化学学报,2001,22(3):399-402. |
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| 作者姓名： | 胡建军 巨勇 赵玉芬 |
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| 作者单位： | 清华大学生命科学与工程院, 化学系, |
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| 基金项目： | 国家自然科学基金! (批准号 :3 9870 415，2 9672 0 2 2 )资助 |
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| 摘 要： | 研究了N－（O，O－二异丙基）磷酰化－L－（或D－）丝氨酸和L－（或D－）组氨酸在水溶液中的反应及其与L－（或D－）组氨酸甲酯在DMSO中的反应，用SDS作对离子试剂，采用离子对反相高效液相色谱方法及反应产物进行分析。结果表明，所有反应体系中均有丝组二肽生成，而L－L和D－D型丝组二肽的生成量约是L－D和D－L型产物的4倍。
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| 关 键 词： | N－（O O－二异丙基）磷酰化丝氨酸 丝组二肽 立体选择 成肽反应 离子对反相高效液相色谱 |
| 文章编号： | 0251-0790(2001)03-0399-04 |
Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine |
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| HU Jian-jun,JU Yong,ZHAO Yu-Fen.Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine Stereo-effect of the Peptide Formation Reaction by N-(O,O-Diisopropyl) Phosphoryl Serine[J].Chemical Research In Chinese Universities,2001,22(3):399-402. |
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| Authors: | HU Jian-jun JU Yong ZHAO Yu-Fen |
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| Abstract: | The reactions between N phosphoryl L (or D ) serine and L (or D ) histidine or L (or D ) histidine methyl ester were investigated. Products of the reaction mixtures were analyzed by ion pair reversed phase HPLC with SDS as the ion pairing reagent. The results showed that dipeptide serylhistidine was formed in all these reaction systems, and L L and D D types of serylhistidine were yielded in an amount about four times as much as that of the L D and D L type dipeptide. |
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| Keywords: | Chirality N ( O O diisopropyl) phosphoryl serine Ion paired RP HPLC Serylhistidine Stereoselectivity |
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