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| [99mTcN(PNP5)(NOEt)]+新型心肌灌注显像剂研究 | |
| 引用本文： | 楚进锋,李彬,孔德靖,王学斌,张俊波,王金城,米宏志,赵建冬.[99mTcN(PNP5)(NOEt)]+新型心肌灌注显像剂研究[J].高等学校化学学报,2005,26(6):1014-1017. |
| 作者姓名： | 楚进锋 李彬 孔德靖 王学斌 张俊波 王金城 米宏志 赵建冬 |
| 作者单位： | 1. 北京化工大学理学院,北京,100029 2. 北京师范大学化学系,北京,100875 3. 北京安贞医院核医学科,北京,100029 |
| 摘 要： | 以氯化亚锡为还原剂, SDH(丁二酰二酰肼)为供氮体, 经配体交换反应得到99mTcN(PNP5)·(NOEt)]+, 通过TLC和HPLC分析, 其放化纯度大于90%. 该标记物是一种体外稳定性良好的阳离子配合物, 在小鼠和狗体内的心肌初始摄取量高, 滞留好, 肝和肺等非靶组织清除快, 有利于早期心肌显像, 有望成为一种新型的心肌灌注显像剂. |
| 关 键 词： | 心肌灌注显像剂 生物分布 |
| 文章编号： | 0251-0790(2005)06-1014-04 |
Novel Potential Myocardial Perfusion Imaging Agent [99mTcN(PNP5)(NOEt)]+ |
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| CHU Jin-Feng,LI Bin,KONG De-Jing,WANG Xue-Bin,ZHANG Jun-bo,WANG Jin-Cheng,MI Hong-Zhi,Zhao Jian-dong.Novel Potential Myocardial Perfusion Imaging Agent [99mTcN(PNP5)(NOEt)]+[J].Chemical Research In Chinese Universities,2005,26(6):1014-1017. | |
| Authors: | CHU Jin-Feng LI Bin KONG De-Jing WANG Xue-Bin ZHANG Jun-bo WANG Jin-Cheng MI Hong-Zhi Zhao Jian-dong |
| Abstract: | was prepared through ligand exchange reaction and its radiochemical purity was over 90% measured by TLC and HPLC. The results of charge character and stability studies indicate that ~+ is a cation with a good stability. Studies on the biodistribution in mice and SPECT imaging in dog show that ~(99m)TcN(PNP5)(NOEt)]~+ possessed a high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent. |
| Keywords: | 99mTc |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |