| 含乳糖聚电解质靶向微胶囊的层层自组装构筑 |
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| 引用本文： | 高遐,张馥,陈志春,林贤福.含乳糖聚电解质靶向微胶囊的层层自组装构筑[J].高等学校化学学报,2011,32(4):957-963. |
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| 作者姓名： | 高遐 张馥 陈志春 林贤福 |
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| 作者单位： | 浙江大学化学系; |
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| 基金项目： | 国家自然科学基金(批准号:20874086)资助 |
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| 摘 要： | 设计合成了己二酸乳糖乙烯酯/对苯乙烯磺酸钠共聚物(PLESS),通过层层自组装技术构筑聚烯丙基胺盐酸盐(PAH)与含乳糖聚电解质PLESS的靶向微胶囊.以紫外-可见吸收光谱检测PAH与PLESS在平面石英片上的层层自组装过程,研究不同实验条件(聚电解质浓度、溶液盐度、盐种类)对PAH/PLESS多层膜自组装的影响.结果...
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| 关 键 词： | 乳糖 层层自组装 微胶囊 肝靶向性 生物相容性 |
| 收稿时间： | 2010-07-23 |
Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte |
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| GAO Xia,ZHANG Fu,CHEN Zhi-Chun,LIN Xian-Fu.Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte[J].Chemical Research In Chinese Universities,2011,32(4):957-963. |
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| Authors: | GAO Xia ZHANG Fu CHEN Zhi-Chun LIN Xian-Fu |
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| Institution: | GAO Xia,ZHANG Fu,CHEN Zhi-Chun,LIN Xian-Fu(Department of Chemistry,Zhejiang University,Hangzhou 310027,China) |
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| Abstract: | Hepatic-targeting microcapsules were constructed by layer-by-layer(LBL) self-assembly of poly(allylamine hydrochloride)(PAH) and chemo-enzymatic synthesized poly(vinyl lactose ester-co-sodium p-styrenesulfonate)(PLESS) containing lactose branches.Alternate deposition of PAH and PLESS was carried out on different solid surfaces such as quartz slides and CaCO3 microparticles.The self-assembly nature of the novel polyelectrolytes was investigated in detail by varying polyelectrolytes concentration,ionic streng... |
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| Keywords: | Lactose Layer-by-layer self-assembly Microcapsule Hepatic targeting Biocompatibility |
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