激光解吸电离质谱新型液相基质研究

选用包括纳米粒子在内的多种基质化合物，构成了多种不同组成的液相基质。以多肽、蛋白、大环寡糖和有机小分子等数种类型化合物为样品，系统地考察了不同液相基质在基质辅助激光解吸电离飞行时间质谱（MALDI－TOF）分析中的应用情况，探讨了与固体制样方法的异同点。实验结果表明，有些液相基质对多类化合物具有较好的通用性，而有些液相基质对某些特定型化合物的分析特别有效。

Studies on the New Liquid Matrix for Laser Desorption/ Ionization Mass Spectrometry

Several liquid matrixes with different compositions were formed by using some matrice compounds including nanoparticles, and their applications in matrix assisted laser desorption/ionization time of flight mass spectrometry were systematically investigated with several kinds of compounds such as peptide, protein, macrocycle oligosaccharide, small organic molecules as the testing samples. The similarities and differences between solid and liquid method of sample preparation were explored. It is shown from the experimental results that some liquid matrixes possessed a good versatility and the others are especially efficient to the analysis of particular compounds.