| 光诱导富精氨酸多肽修饰的Fe2O3@Au纳米粒子的细胞毒性 |
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| 引用本文： | 刘桂锋,高忠礼,余琼,张惠茅,王振新.光诱导富精氨酸多肽修饰的Fe2O3@Au纳米粒子的细胞毒性[J].高等学校化学学报,2012,33(9):1920-1925. |
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| 作者姓名： | 刘桂锋 高忠礼 余琼 张惠茅 王振新 |
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| 作者单位： | 吉林大学中日联谊医院;中国科学院长春应用化学研究所电分析国家重点实验室 |
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| 基金项目： | 科技部纳米重大研究计划(批准号:2011CB935800)资助 |
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| 摘 要： | 以人宫颈癌细胞(HeLa细胞)为对象考察了富精氨酸多肽RRRRRRRR(R8)修饰的金-三氧化二铁壳核纳米粒子(R8-Fe2O3@Au NPs)对活细胞的光毒性. 研究结果表明, 内化后的R8-Fe2O3@Au NPs对活HeLa细胞无显著的细胞毒性, 但在激光照射下则可导致HeLa细胞的凋亡, 表现出很强的细胞光毒性. R8-Fe2O3@Au NPs的细胞光毒性与照射激光波长有关, 并随细胞吞噬的R8-Fe2O3@Au NPs的量、 光照强度和时间的增加而增强.
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| 关 键 词： | 金-三氧化二铁壳核纳米粒子 多肽 光毒性 活细胞 |
| 收稿时间： | 2011-11-18 |
Light Induced Cellular Cytotoxicity of Rich Arginine Peptide Modified Ferric Oxide Core Gold Shell Nanoparticles |
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| LIU Gui-Feng,GAO Zhong-Li,YU Qiong,ZHANG Hui-Mao,WANG Zhen-Xin.Light Induced Cellular Cytotoxicity of Rich Arginine Peptide Modified Ferric Oxide Core Gold Shell Nanoparticles[J].Chemical Research In Chinese Universities,2012,33(9):1920-1925. |
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| Authors: | LIU Gui-Feng GAO Zhong-Li YU Qiong ZHANG Hui-Mao WANG Zhen-Xin |
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| Institution: | 1.China-Japan Union Hospital,Jilin University,Changchun 130033,China; 2.State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022,China) |
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| Abstract: | The laser induced cellular cytotoxicity of rich arginine peptide RRRRRRRR(R8) modified ferric oxide core gold shell nanoparticles(R8-Fe2O3@Au NP) was studied. Although R8-Fe2O3@Au NP has a low cytotoxicity, the viability of nanoparticles internalized HeLa cell can be decreased by laser irradiation. The experimental result indicates that the R8-Fe2O3@Au NPs have significant cellular phototoxicity under laser irradiation. In addition, the cellular phototoxicity of R8-Fe2O3@Au NPs is dependent on the wavelength of irradiation laser, and increased by the irradiating time and light intensity. |
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| Keywords: | Fe2O3@Au nanoparticles" target="_blank">2O3@Au nanoparticles')" href="#">Fe2O3@Au nanoparticles Peptide Phototoxicity Living cell |
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