| 新型含悬挂羧基聚乳酸的制备及其血液相容性和细胞粘附性 |
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| 引用本文： | 王蔚,贾小华,刘媛,王亮,袁直,汤石明,刘民,汤华.新型含悬挂羧基聚乳酸的制备及其血液相容性和细胞粘附性[J].高等学校化学学报,2008,29(2):433-435. |
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| 作者姓名： | 王蔚 贾小华 刘媛 王亮 袁直 汤石明 刘民 汤华 |
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| 作者单位： | 1. 南开大学高分子研究所,功能高分子材料教育部重点实验室,天津,300071
2. 天津医科大学天津市生命科学中心实验室,天津,300070 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 制备了乳酸-苹果酸共聚物(PLMA), 并在前期工作的基础上制备了悬挂羧基聚乳酸(PLMACA), 考察了手臂长度及端功能基团对改善聚乳酸的血液相容性及细胞粘附性的影响. 结果表明, PLMACA同时具有良好的血液相容性和细胞亲和性, 极有可能成为新一代血管(修复)材料.
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| 关 键 词： | 聚乳酸 血液相容性 内皮细胞 粘附 |
| 文章编号： | 0251-0790（2008）02-0433-03 |
| 收稿时间： | 2007-09-05 |
| 修稿时间： | 2007年9月5日 |
Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion |
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| WANG Wei,JIA Xiao-Hua,LIU Yuan,WANG Liang,YUAN Zhi,TANG Shi-Ming,LIU Min,TANG Hua.Preparation of Functionalized PLA with Pendant Carboxyl and Its Blood Compatibility and Cell Adhesion[J].Chemical Research In Chinese Universities,2008,29(2):433-435. |
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| Authors: | WANG Wei JIA Xiao-Hua LIU Yuan WANG Liang YUAN Zhi TANG Shi-Ming LIU Min TANG Hua |
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| Institution: | Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China;;Laboratory of Tianjin Life Science Research Center, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | Biodegradable α-hydroxyl polyesters, such as poly(lactic acid)(PLA) and poly(lactic-co-glycolic acid)(PLGA) were investigated as scaffolds for tissue engineering. However, polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells. In this study, the functional polylactide with pendant carboxyl(PLMACA) was synthesized, which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA. The structure and composition of PLMACA were confirmed via 1H NMR spectrum and the compatibilities for blood and cell were stu-died. The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion. |
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| Keywords: | Polylactide Blood compatibility Human umbilical vein endothelial cell(HUVEC) Adhesion |
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