| 楔形短肽表面活性剂A3V3D纳米自组装结构的表征及机理研究 |
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| 引用本文： | 陈咏竹,邱峰,赵晓军.楔形短肽表面活性剂A3V3D纳米自组装结构的表征及机理研究[J].高等学校化学学报,2009,30(7):1337-1341. |
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| 作者姓名： | 陈咏竹 邱峰 赵晓军 |
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| 作者单位： | 四川大学华西医院纳米生物医学技术与膜生物学研究所,成都,610041 |
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| 摘 要： | 通过对传统短肽表面活性剂氨基酸序列的改良, 设计了具有楔形几何结构的新型短肽表面活性剂A3V3D. 圆二色谱(CD)分析表明, 该短肽的二级结构为无规则卷曲, 透射电子显微镜(TEM)和原子力显微镜(AFM)表征发现, 该短肽在水溶液中能够发生有序的自组装, 形成稳定的光滑平直的纳米纤维. 芘探针荧光光谱分析显示, 该短肽形成了疏水区并将芘分子包裹其中. 由此推测A3V3D在其楔形几何结构的影响下, 以柱状胶束的形式发生自组装, 是一种新型的自组装短肽材料, 说明了几何形状效应在控制短肽的自组装行为中起着关键作用.
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| 关 键 词： | 自组装 短肽表面活性剂 几何形状效应 纳米纤维 |
| 收稿时间： | 2008-12-10 |
Self-assembling Structure and Mechanism of a Wedge-shaped Peptide Detergent A3V3D |
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| CHEN Yong-Zhu,QIU Feng,ZHAO Xiao-Jun.Self-assembling Structure and Mechanism of a Wedge-shaped Peptide Detergent A3V3D[J].Chemical Research In Chinese Universities,2009,30(7):1337-1341. |
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| Authors: | CHEN Yong-Zhu QIU Feng ZHAO Xiao-Jun |
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| Institution: | Institute for Nanobiomedical Technology and Membrane Biology;West China Hospital;Sichuan University;Chengdu 610041;China |
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| Abstract: | A wedge-shaped peptide detergent A3V3D was designed by changing the amino acid sequence of traditional peptide detergents. Although the secondary structure of this peptide is random coil as revealed by circular dichroism(CD) assessment,it can still undergo well-ordered self-assemble in water solution into stable,smooth and straight nanofibers,which are observed by transmission electron microscopy(TEM) and atomic force microscopy(AFM). Pyrene probe fluorescence analysis indicated that it could form hydrophob... |
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| Keywords: | Self-assembly Peptide detergent Geometrical shape effect Nanofiber |
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