一些2-氨基-1,3,4-噻二唑类化合物的合成及其对水稻白叶枯病菌活性的研究

为了筛选防治水稻白叶枯病的新药剂,合成了16个2-氨基-5-烷基-1,3,4-噻二唑(Ⅰ)(其中7个是新化合物),11个O,O-二苯基-N-(5-烷基-1,3,4-噻二唑-2-基)磷酰胺(Ⅱ)及4个O,O-二烷基-S-(N-1,3,4-噻二唑)胺基甲基二硫代磷酸酯(Ⅲ)。对水稻白叶枯病原菌和桃冠瘿病原菌进行了离体药效试验,结果表明Ⅰ、Ⅱ类化合物均有活性,且活性的大小与5-位正烷基的碳原子数有关。

The Bactericidal Activity of Some 2-Amino-5-Alkyl-1,3,4-Thiadiazoles

With the purpose of seeking more effective, less hazardous bactericides against rice leaf blight, there were synthesized sixteen 2-amino-5-alkyl-l,3, 4-thiadia-zoles (Ⅰ) (among them seven new compounds) and eleven O,O-diphenyl phosp-horyl amides of various 2-amino-5-alkyl-1,3,4-thiadiazoles (Ⅱ), as well as four O,O-dialkyl-S-(N-l,3,4-thiadiazole) aminomethyldithio-phosphorates (Ⅲ). All these compounds were tested against xanthomonas campestris pv.oryzae or Agrobacterium tumcufacenec in vitro. The biological evaluation results showed that compounds of types Ⅰ and Ⅱ were active and the activity was correlative with the length of the n-alkyl at 5 position.