| 聚L-谷氨酸担载胰岛素口服微球的制备与评价 |
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| 引用本文： | 韩亚冬,夏加亮,何盼,田华雨,陈学思,景遐斌.聚L-谷氨酸担载胰岛素口服微球的制备与评价[J].高等学校化学学报,2009,30(12). |
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| 作者姓名： | 韩亚冬 夏加亮 何盼 田华雨 陈学思 景遐斌 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春,130022;中国科学院研究生院,北京,100039
2. 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室,长春,130022 |
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| 基金项目： | 国家自然科学基金，A3国际合作重大基金，科技部国际合作重点项目，吉林省科技发展计划国际合作项目 |
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| 摘 要： | 以聚L-谷氨酸为载体材料,采用无水乳液法制备了口服胰岛素微球,微球直径在5～20 μm,载药质量分数为5%～9%.载药微球具有良好的pH敏感释放行为,在胃模拟液中2 h释放量约为5%,在肠道模拟液中2 h释放90%以上.考察聚合物分子量、溶液浓度、理论投药量及混合材料对微球释放行为的影响.
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| 关 键 词： | 聚L-谷氨酸 微球 口服胰岛素 无水乳液 pH敏感药物释放 Poly ( α L-glutamic acid) |
Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery |
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| HAN Ya-Dong,XIA Jia-Liang,HE Pan,TIAN Hua-Yu,CHEN Xue-Si,JING Xia-Bin.Poly(α,L-glutamic acid) Microspheres for Oral Insulin Delivery[J].Chemical Research In Chinese Universities,2009,30(12). |
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| Authors: | HAN Ya-Dong XIA Jia-Liang HE Pan TIAN Hua-Yu CHEN Xue-Si JING Xia-Bin |
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| Institution: | HAN Ya-Dong1,2,XIA Jia-Liang1,HE Pan1,TIAN Hua-Yu1,CHEN Xue-Si1,JING Xia-Bin1(1.State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun 130022,China,2.Graduate School of Chinese Academy of Sciences,Beijing 100039,China) |
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| Abstract: | Insulin-loaded poly(α,L-glutamic acid) microspheres for oral delivery were prepared by anhydrous emulsion system. The microspheres had diameters of 5-20 μm, and drug loading of 5%-9%. The microspheres had good pH sensitive release behavior. In gastric simulated fluid about 5% of insulin was released from microspheres after 2 h, while in intestinal simulated fluid over 90% of insulin released. The effect of polymer molecular weight, theoretical drug loading and polymer solution concentration to the microsphere release profile were investigated. |
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| Keywords: | Microsphere Oral insulin delivery Anhydrous emulsion pH-sensirive drug release |
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