| 降压药阿雷地平及其相关杂质的合成与表征 |
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| 引用本文： | 李晶,苏伟,王学元,傅鹏,孙艳.降压药阿雷地平及其相关杂质的合成与表征[J].高等学校化学学报,2022,43(2):20210663-41. |
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| 作者姓名： | 李晶 苏伟 王学元 傅鹏 孙艳 |
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| 作者单位： | 1.天津大学化工学院, 天津 300072;2.盈科瑞(天津)创新医药研究有限公司, 天津 300385;3.天津大学理学院化学系, 天津 300072 |
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| 基金项目： | 天津市应用基础与前沿技术研究计划(批准号:14JCYBJC21200)资助。 |
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| 摘 要： | 建立了降压药阿雷地平新的合成路线, 并讨论了新合成方法的优化条件, 反应整体收率提高了20%; 结合阿雷地平的结构特点和合成工艺分析出6种杂质, 并提供了其制备方法和表征结果; 采用高效液相色谱(HPLC)法测定阿雷地平中的相关杂质, 为其质量标准的制定提供了实验依据.
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| 关 键 词： | 阿雷地平 杂质 高效液相色谱 |
| 收稿时间： | 2021-09-13 |
Synthesis and Characterization of Antihypertensive Drug Aranidipine and Its Related Impurities |
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| LI Jing,SU Wei,WANG Xueyuan,FU Peng,SUN Yan.Synthesis and Characterization of Antihypertensive Drug Aranidipine and Its Related Impurities[J].Chemical Research In Chinese Universities,2022,43(2):20210663-41. |
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| Authors: | LI Jing SU Wei WANG Xueyuan FU Peng SUN Yan |
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| Institution: | 1.School of Chemical Engineering, Tianjin University, Tianjin 300072, China;2.Increase(Tianjin) Innovative Medicine Research Co. , Ltd. , Tianjin 300385, China;3.Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China |
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| Abstract: | In this paper， a high-yield synthetic scheme of aranidipine was created. The optimization conditions of the new synthetic method were discussed， and the overall yield increased by 20%. Through the structural characteristics and synthetic process， six kinds of Aranidipine impurities were found， whose preparation methods and characte-rization were provided in the meantime. Moreover， the high performance liquid chromatography（HPLC） method was established for the determination of related impurities in Aranidipine， and was able to supply an experimental basis for the formulation of its quality standard. |
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| Keywords: | Aranidipine Impurity High performance liquid chromatography |
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