| 新型金属卟啉的合成及其仿酶活性研究 |
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| 引用本文： | 李早英,张悦宁,朱训进,冯清.新型金属卟啉的合成及其仿酶活性研究[J].高等学校化学学报,2002,23(5):756-762. |
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| 作者姓名： | 李早英 张悦宁 朱训进 冯清 |
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| 作者单位： | 1. 武汉大学化学与分子科学学院, 武汉 430072;
2. 华中科技大学同济医学院, 武汉 430030 |
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| 基金项目： | 国家自然科学基金（批准号：29972035），武汉大学2000年自强科学基金资助． |
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| 摘 要： | 合成并表征了一系列水溶性和非水溶性金属卟啉3a～3e,5a～5f和8a～8f;测试了这些金属卟啉作为超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的模拟物催化歧化O2-和催化分解H2O2等有毒氧自由基的活性及抗脂质过氧化性质.结果表明,含有吡啶溴化盐的水溶性金属卟啉8a～8f的仿酶活性明显大于含有羟基的非水溶性金属卟啉3a～3e和含有酯基的金属卟啉5a～5f.
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| 关 键 词： | 金属卟啉 合成 表征 仿酶活性测试 |
| 文章编号： | 0251-0790(2002)05-0756-07 |
| 收稿时间： | 2001-07-27 |
Synthesis of Novel Metalloporphyrins and Their Biological Activity as Mimics of Enzymes |
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| LI Zao-Ying,ZHANG Yue-Ning,ZHU Xun-Jin,FENG Qing.Synthesis of Novel Metalloporphyrins and Their Biological Activity as Mimics of Enzymes[J].Chemical Research In Chinese Universities,2002,23(5):756-762. |
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| Authors: | LI Zao-Ying ZHANG Yue-Ning ZHU Xun-Jin FENG Qing |
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| Institution: | 1. College of Chemistry and Molecular Science, Wuhan University, Wuhan 430072, China;
2. College of Tongji Medicine, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | Based on 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin(2),a series of non-water soluble and water-soluble metalloporphyrins were synthesized.As mimics of SOD (superoxide dismutase) and CAT(catalase) enzymes, metalloporphyrins 3a-3e, 5a-5f,and 8a-8f, were tested in the assays to dismutase O2-, to decompose H2O2,to clear OH,and to eliminate lipid peroxidation produced in the ho-mogenated livers of mice.Among these metalloporphyrins, 8a-8f, were most effective.Some rules were obtained from the biological activity testing results. |
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| Keywords: | Metalloporphyrins Synthesis Characterizaion Determination of Biological activity of mimic enzymes |
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