| 端基为肝靶向基团的聚谷氨酸苄酯的合成及表征 |
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| 引用本文： | 查瑞涛,杜田,袁直.端基为肝靶向基团的聚谷氨酸苄酯的合成及表征[J].高等学校化学学报,2006,27(5):885-887. |
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| 作者姓名： | 查瑞涛 杜田 袁直 |
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| 作者单位： | 功能高分子材料教育部重点实验室,南开大学高分子化学研究所,天津,300071 |
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| 基金项目： | 教育部天津大学-南开大学科技合作基金 |
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| 摘 要： | 本文研究甘草次酸、 甘草酸和胆酸的二胺类衍生物的合成及其引发谷氨酸苄酯-N-羧酸酐的开环聚合, 合成了在端基具有不同肝靶向识别基团的聚谷氨酸苄酯. 该材料可能具有肝细胞主动靶向作用, 为进一步的肝靶向药物控释的研究奠定了基础.
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| 关 键 词： | 肝靶向 甘草酸 甘草次酸 胆酸 聚谷氨酸苄酯 |
| 文章编号： | 0251-0790（2006）05-0885-03 |
| 收稿时间： | 09 14 2005 12:00AM |
| 修稿时间： | 2005-09-14 |
Syntheses and Characterization of Poly(γ-benzyl-L-glutamate) Containing Liver Targeting Group in Main Chain |
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| CHA Rui-Tao,DU Tian,YUAN Zhi.Syntheses and Characterization of Poly(γ-benzyl-L-glutamate) Containing Liver Targeting Group in Main Chain[J].Chemical Research In Chinese Universities,2006,27(5):885-887. |
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| Authors: | CHA Rui-Tao DU Tian YUAN Zhi |
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| Institution: | Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | Started from the liver targeting compounds(glycyrrhizin,glycyrrhetinicacid,bile acid),six(amine-terminated) compounds were prepared via two-step reactions.The NMR experiments provided the direct evidence of the existence of amide.The polymers were synthesized by polymerizing of BLG-NCA initiated by each of six amine-terminated compounds.The liver targeting group was introduced to the main chain of the polymer.The molecular weight of the resultant polymers was adjusted by changing the molar ratio of monomer BLG-NCA to initiator.The product structure was characterized by GPC,FTIR and()~(1)H NMR.The results demonstrate that amine-terminated compounds containing liver targeting group could initiate the polymerization of BLG-NCA. |
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| Keywords: | Target of liver Glycyrrhizin Glycyrrhetinic acid Bile acid Poly(γ-benzyl-L-glutamate) |
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