| 金纳米花介导的近红外热疗对人喉癌Hep-2细胞增殖的抑制作用 |
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| 引用本文： | 宋文植,姜雅萍,纪小会,赵丽丽,尹万忠,杨文胜.金纳米花介导的近红外热疗对人喉癌Hep-2细胞增殖的抑制作用[J].高等学校化学学报,2012,33(9):1886-1888. |
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| 作者姓名： | 宋文植 姜雅萍 纪小会 赵丽丽 尹万忠 杨文胜 |
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| 作者单位： | 1. 吉林大学中日联谊医院, 长春 130033;
2. 吉林大学化学学院;
3. 吉林大学第一临床医院, 长春 130012 |
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| 基金项目： | 吉林省科技发展计划项目(批准号:20110708);国家自然科学基金(批准号:50825202)资助 |
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| 摘 要： | 采用弱配体柠檬酸钠修饰的金纳米花为介导材料,考察了其对人喉癌Hep-2细胞的NIR热疗作用,结果表明,这种金纳米花材料具有良好的NIR光热转换性能,可有效抑制Hep-2细胞增殖.
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| 关 键 词： | 金纳米花 柠檬酸钠 近红外热疗 人喉癌Hep-2细胞 热消融 |
| 收稿时间： | 2012-04-28 |
Inhibition Effect of NIR Photothermal Therapy Mediated by Gold Nanoflowers on Proliferation of Human Laryngocarcinoma Hep-2 Cells |
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| SONG Wen-Zhi,JIANG Ya-Ping,JI Xiao-Hui,ZHAO Li-Li,YIN Wan-Zhong,YANG Wen-Sheng.Inhibition Effect of NIR Photothermal Therapy Mediated by Gold Nanoflowers on Proliferation of Human Laryngocarcinoma Hep-2 Cells[J].Chemical Research In Chinese Universities,2012,33(9):1886-1888. |
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| Authors: | SONG Wen-Zhi JIANG Ya-Ping JI Xiao-Hui ZHAO Li-Li YIN Wan-Zhong YANG Wen-Sheng |
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| Institution: | 1. China-Japan Union Hospital, Jilin University, Changchun 130033, China;
2. College of Chemistry;
3. The First Clinical Hospital, Jilin University, Changchun 130012, China |
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| Abstract: | Citrate-capped gold nanoflowers(GNFs) prepared by seeding approach were identified to show efficiently photothermal conversion under the irradiation of 808 nm near-infrared laser.MTT3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide] results demonstrate that the photothermal therapy mediated by GNFs inhibits the proliferation of Hep-2 cells effectively,and the inhibition effect increases with the increased concentrations of GNFs and power of the laser.The results of apoptosis and necrosis tested by flow cytometry demonstrate that the photothermal ablation play a predominant role in suppressing the proliferation of the Hep-2 cells.Such citrate-capped GNFs are expected to be a kind of materials potential useful in tumuor NIR photothermal therapy. |
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| Keywords: | Gold nanoflowers Sodium citrate Near-infrared photothermal therapy Human laryngocarcinoma Hep-2 cell Thermal ablation |
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