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Microwave‐Assisted Synthesis of β‐Lactams and Cyclo‐β‐dipeptides |
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| Authors: | Luis G Hernández‐Vázquez Marco A Leyva Alejandro J Metta‐Magaña Jaime Escalante |
| Institution: | 1. Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Av. Universidad No.?1001, Col. Chamilpa, C.P. 62209, Cuernavaca, Mor., México;2. Cinvestav‐I.P.N., Departamento de Química, Av. Instituto Politécnico Nacional 2508, Col. San Pedro Zacatenco, C.P. 07000, México D.F., México;3. Department of Chemistry, University of Texas at El Paso, El Paso, TX 79968‐0513, USA |
| Abstract: | Different cyclo‐β‐dipeptides were prepared from corresponding N‐substituted β‐alanine derivatives under mild conditions using PhPOCl2 as activating agent in benzene and Et3N as base. To evaluate β3‐substituent influence, the amino acids 7 – 26 were synthesized, and a β‐lactam formation reaction was carried out instead of cyclo‐β‐dipeptide formation. The crystal structures of three derivatives of cyclo‐β‐peptides and one β‐lactam are presented. |
| Keywords: | β ‐Lactams Cyclo‐β ‐dipeptides Microwave synthesis β ‐Alanines Amino acids Azetidinones Peptides X‐Ray crystallography |