Steroidal Alkaloids from the Roots and Rhizomes of Vertrum nigrum L. |
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| Authors: | Yue Cong William Jia Jing Chen Shuang Song Jin‐Hui Wang Yu‐Hui Yang |
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| Institution: | 1. School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road?103, Shenyang 110016, China, (phone and fax: +86‐24‐23986479);2. Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada;3. Jinzhou Medical Colledge, Jinzhou 121001, China |
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| Abstract: | Two new steroidal alkaloids, neoverapatuline ( 1 ) and (1β,3α,5β)‐1,3‐dihydroxyjervanin‐12‐en‐11‐one ( 2 ), together with the four known compounds, veratramine ( 3 ), rubijervine ( 4 ), veratrosine ( 5 ), and veratroylzygadenine ( 6 ), were isolated from the roots and rhizomes of Veratrum nigrum L. Their structures were established through combined analyses of physicochemical properties and spectroscopic evidence. All compounds 1 – 6 were tested for their cytotoxicities in vitro against the human glioma cell line SF188. |
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| Keywords: | Veratrum nigrium Steroidal alkaloids Alkaloids Cytotoxic activity Neoverapatuline Jervanin‐12‐en‐11‐one (1β 3α 5β )‐1 3‐dihydroxy‐ |
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