New and Bioactive Sesquiterpenes from Schisandra sphenanthera |
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| Authors: | Khongorzul Mendbayar I‐Wen Lo Chia‐Ching Liaw Yu‐Chi Lin Ahmed E Fazary Yuh‐Chi Kuo Hsiu‐Ju Wang Been Huang Chiang Shorong‐Shii Liou Ya‐Ching Shen |
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| Institution: | 1. School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan, (phone: +886‐2‐23123456, ext. 62226;2. fax: +886‐02‐23919098);3. Department of Life Science, Fu‐Jen University, Taipei Hsien, Taiwan;4. Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan;5. Department of Pharmacy, Tajen University, Ping‐Tung, Taiwan |
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| Abstract: | Three new sesquiterpenes, schisansphenins A ( 1 ) and B ( 2 ) and (?)‐γ‐cuparenol ( 3 ), were isolated from an acetone extract of the fruits of Schisandra sphenanthera. The known compound 4 was isolated for the frist time from a natural source. The structures of the isolated compounds were elucidated through extensive spectroscopic analyses, particularly 2D‐NMR experiments (1H,1H‐COSY, HMQC, HMBC, and NOESY). A plausible biogenetic pathway for schisansphenin B ( 2 ) is proposed. Compounds 2 and 3 significantly reduced activation of NF‐AT and NF‐κB in the luciferase‐reporter assay. |
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| Keywords: | Schisandra sphenanthera Schisansphenins A and B (− )‐γ ‐Cuparenol Immuno‐modulating activity |
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